نتایج جستجو برای: bet thermodynamic

تعداد نتایج: 50013  

2017
Linda Ahammer Sarina Grutsch Michael Wallner Fatima Ferreira Martin Tollinger

In Northern America and Europe a great number of people are suffering from birch pollen allergy and pollen related food allergies. The trigger for these immunological reactions is the 17.5 kDa major birch pollen allergen Bet v 1, which belongs to the family of PR-10 (pathogenesis-related) proteins. In nature, Bet v 1 occurs as a mixture of various isoforms that possess different immunological p...

Journal: :Journal of investigational allergology & clinical immunology 2016
G Ciprandi P Comite M Mussap M De Amici S Quaglini F Barocci G L Marseglia E Scala

BACKGROUND Birch allergy (BA) is a common pollinosis caused by the allergens Bet v 1, Bet v 2, and Bet v 4. Oral allergy syndrome (OAS) is frequently associated with BA. A gradient of sensitization to birch allergen across Europe has been reported. Therefore, this study aimed to investigate the birch sensitization profile, including OAS, across Italy. METHODS We performed a retrospective stud...

Journal: :American journal of clinical pathology 2004
Adam Goldfarb

In this issue of the Journal, Dorfman and colleagues1 describe the usefulness of T-bet as a marker for specific subtypes of B-cell lymphoma. T-bet originally was identified as a T-box family transcription factor that dominantly programs CD4 and CD8 T-cell development along Th1 and Tc1 pathways, respectively.2 It accomplished this impressive task in part through the coordinated transcriptional a...

2015
Suryani Lukman Zeyar Aung Kelvin Sim

BET proteins are epigenetic readers whose deregulation results in cancer and inflammation. We show that BET proteins (BRD2, BRD3, BRD4 and BRDT) are globally similar with subtle differences in the sequences and structures of their N-terminal bromodomain. Principal component analysis and nonnegative matrix factorization reveal distinct structural clusters associated with specific BET family memb...

2016
Jude T. Deeney Anna C. Belkina Orian S. Shirihai Barbara E. Corkey Gerald V. Denis

Displacement of Bromodomain and Extra-Terminal (BET) proteins from chromatin has promise for cancer and inflammatory disease treatments, but roles of BET proteins in metabolic disease remain unexplored. Small molecule BET inhibitors, such as JQ1, block BET protein binding to acetylated lysines, but lack selectivity within the BET family (Brd2, Brd3, Brd4, Brdt), making it difficult to disentang...

Journal: :Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 2011
Szu-Chia Chen Jer-Ming Chang Wan-Chun Liu Jer-Chia Tsai Ling-I Chen Ming-Yen Lin Po-Chao Hsu Tsung-Hsien Lin Ho-Ming Su Shang-Jyh Hwang Hung-Chun Chen

BACKGROUND Patients with chronic kidney disease (CKD) are associated with increased cardiovascular morbidity and mortality. An increase in the ratio of pre-ejection period (PEP) to ejection time (ET) is correlated with an increase in left ventricular mass index (LVMI) and a decrease in left ventricular ejection fraction (LVEF). Brachial PEP (bPEP) and brachial ET (bET) can be automatically dete...

Journal: :Journal of immunology 2005
Weifeng Xu J Jillian Zhang

During the adaptive phase of an immune response, naive B cells receive multiple signals to become activated. Among them are the engagement of the B cell Ag receptor and stimulation by cytokines. Specifically for an anti-microbial response, the recognition of viral or bacterial Ags by the BCR and the stimulation of IFN-gamma result in the predominant production of IgG2a. The T-bet protein has be...

2012
Anette C. Karle Gertie J. Oostingh Sonja Mutschlechner Fatima Ferreira Peter Lackner Barbara Bohle Gottfried F. Fischer Anne B. Vogt Albert Duschl

Nitration of pollen derived allergens can occur by NO(2) and ozone in polluted air and it has already been shown that nitrated major birch (Betula verrucosa) pollen allergen Bet v 1.0101 (Bet v 1) exhibits an increased potency to trigger an immune response. However, the mechanisms by which nitration might contribute to the induction of allergy are still unknown. In this study, we assessed the e...

Journal: :Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2017
Yun Xu Lujun Chen Bin Xu Yuqi Xiong Min Yang Xiaohui Rui Liangrong Shi Changping Wu Jingting Jiang Binfeng Lu

BACKGROUND/AIMS T-bet, a member of the T-box family of transcription factors, is a key marker of type I immune response within the tumor microenvironment, and has been previously reported by us to serve as an important prognostic indicator for human gastric cancer patients and a potential biomarker for immunotherapy. In the present study, we aimed to assess the clinical significance and prognos...

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Citrate was used as chelating or morphology regulating agent in this study. In the presence of regulating agent a two-dimensional monetite phase evolved into  three-dimentional hydroxyapatite microspheres with an average diameter of 4 µm. Scanning electron microscopy (SEM) and transmission electron microscopy (TEM) studies revealed the importance of Ca/citrate ratio in regulating the particle m...

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