From in vitro studies, flap endonuclease 1 (FEN1) has been proposed to play a role in the long patch (LP) base excision repair (BER) subpathway. Yet the role of FEN1 in BER in the context of the living vertebrate cell has not been thoroughly explored. In the present study, we cloned a DT40 chicken cell line with a deletion in the FEN1 gene and found that these FEN1-deficient cells exhibited hyp...

Performance of cross-layer protocols that recommend the relay of corrupted packets to higher layers can be improved significantly by accurately inferring/predicting the bit error rate (BER) in the packets. Here, inference refers to estimating the BER in an already received packet, while prediction specifically refers to anticipating the BER in a future packet. This paper presents a measurement ...

A Chunk by chunk-based allocation is an emerging subcarrier allocation in Single Carrier Frequency Division Multiple Access (SC-FDMA) due to its low complexity. In this paper, a combined userorder and chunk-order allocation for solving chunk allocation problem which minimizes the average BER of all users while improving the throughput in SC-FDMA uplink is proposed. The subcarrier grouping into ...

The incidence of Aspergillus fumigatus infections has become more frequent as a consequence of widespread immunosuppression. At present, the number of available antifungal agents in the clinic is limited, and most of them, such as itraconazole (ICZ), are toxic and show resistance. Berberine (BER) is a plant alkaloid used in the clinic mainly for alimentary infections. We have used BER and ICZ t...

The Mre11/Rad50/Xrs2 (MRX) complex in Saccharomyces cerevisiae has well-characterized functions in DNA double-strand break processing, checkpoint activation, telomere length maintenance and meiosis. In this study, we demonstrate an involvement of the complex in the base excision repair (BER) pathway. We studied the repair of methyl-methanesulfonate-induced heat-labile sites in chromosomal DNA i...

During mammalian base excision repair (BER) of lesion-containing DNA, it is proposed that toxic strand-break intermediates generated throughout the pathway are sequestered and passed from one step to the next until repair is complete. This stepwise process is termed substrate channeling. A working model evaluated here is that a complex of BER factors may facilitate the BER process. FLAG-tagged ...

Blossom-end rot (BER) is a physiological disorder related to calcium (Ca) deficiency in tomato fruits. However, adequate Ca supply not sufficient inhibit the BER incidence. The Ni-Ca interact...

The flaw in 5G orthogonal frequency division multiplexing (OFDM) becomes apparent high-speed situations. Because the doppler effect causes shifts, orthogonality of OFDM subcarriers is broken, lowering both their bit error rate (BER) and throughput output. As part this research, we use a novel design that combines massive multiple input output (MIMO) weighted overlap add (WOLA) to improve perfor...

To elucidate the nature of the cross-talk between the p53 protein and the DNA repair machinery, we have investigated the relationship between the two throughout the cell cycle. Base excision repair (BER) was analyzed in cell cycle phase-enriched populations of lymphoid cells expressing wild-type p53. Our study yielded the following novel findings: (a) BER exhibited two distinct peaks of activit...