has long been used as a Chinese folk medicine in the treatment of edema and scrofula. The constituents of L. stenocephala have been previously investigated and shown to contain benzofuran derivatives. Here, we report the isolation and structural elucidation of three new dimeric benzofuran derivatives, ligulacephalins A (1), B (2) and C (3), together with three known compounds from the roots of ...

In the presence of p-toluenesulfonic acid and iodine, styrene derivatives undergo head-to-tail dimerization followed by trapping with nitriles to yield the corresponding Ritter-type products.

A new series of D-π-A type imidazole derivatives have been synthesized and characterized. Two corresponding imidazolium salts (iodine and hexafluorophosphate) were prepared from the imidazole compound. Their electron-withdrawing ability can be largely tunable by salt formation reaction or ion exchange. UV-vis absorption and single-photon fluorescence spectra have been systematically investigate...

In the present study, we synthesized a series of novel 7-methoxy-N-(substituted phenyl)benzofuran-2-carboxamide derivatives in moderate to good yields and evaluated their neuroprotective and antioxidant activities using primary cultured rat cortical neuronal cells and in vitro cell-free bioassays. Based on our primary screening data with eighteen synthesized derivatives, nine compounds (1a, 1c,...

Iodine reacts readily with many proteins and has been used as a group-specific reagent to study the relationship between enzyme and group activity (see, for instance, (1, 2)) (3). Iodoprotein derivatives have also been prepared as electron dense protein crystals for use in x-ray investigations (4). At very low levels of iodination, radioactively labeled iodoproteins have been employed as tracer...

Fluorination of styrene derivatives with a reagent system composed of μ-oxo-bis[trifluoroacetato(phenyl)iodine] and a pyridine·HF complex gave the corresponding (2,2-difluoroethyl)arenes in good yields. Similarly, the reagent of PhI(OCOCF3)2 and the pyridine·HF complex acted as a fluorinating agent for styrene derivatives. The fluorination of styrene derivatives with the pyridine·HF complex und...