Introduction. Compounds based on fused imidazole derivatives can become the basis for development of a new generation clinical therapeutic agents more effective treatment resistant human bacterial infections. This requires research, including design, synthesis, and screening biologically active compounds this group. The aim. To study effect polyfunctional benzimidazole survival Escherichia coli...

The purpose of the present study was to identify the cellular processes and targets affected by treatment with bis-benzimidazole derivatives with chloroalkyl and bromoalkyl moieties (1-4) in the estrogen receptor-negative MDA-MB-231 human breast cancer cells. Treatment of the cells revealed that these compounds inhibited DNA synthesis and irreversibly inhibited the proliferative activity of the...

We report synthesis of novel series of amino alcohol derivatives of 2-methyl benzimidazole. These compounds have been synthesized by epoxide ring opening of 2-methyl benzimidazole with different substituted cyclic amines. These synthesized compounds have been characterized using IR, H NMR and ES-MS spectral data together with their melting point. These compounds (4a-4o) were evaluated for their...

Emerson and associates (1) noted that 2,5-dimethylbenzimidazole appeared to act as a growth depressant when fed to rats in tests of compounds for vitamin Blz-like activity. This property was not exhibited by benzimidazole or any of the other monoor dimethylbenzimidazoles studied. They remarked that 2,5-dimethylbenzimidazole might have “inhibitor activity.” 2,5-Dimethylbenzimidazole inhibited re...