Herein, we report a bulky variant of bis-benzimidazole carboxylate ligand. The five-position the benzimidazole groups were substituted with tertiary butyl intention preventing bis-ligation and oligomerization, as was observed in other studies using similar ligands. Unfortunately, even bulkier substituents, new ligand still formed bis-ligated structure. Although did not afford desired mono-ligat...

Introduction: Oxidative stress and resulting lipid peroxidation are involved in numerous pathological conditions. For this reason, the role of antioxidants attracts attention radical-scavenging capacity many natural synthetic supplements drugs has been extensively evaluated. Material methods: In present study, seven N,N'-disubstituted benzimidazole-2-thiones with ester (1 - 4) hydrazide (5 7) s...

Four bipolar molecules, named 1-, 2-, 3-, and 4-3cbzBIZ, composed of tricarbazole (3cbz) substituted benzimidazole, were synthesized characterized.

Benzimidazole and its derivatives are molecules that have diverse biological properties, therefore we synthesized studied a new benzimidazole to understand their physical/chemical properties. The compound was obtained through synthetic route, using graphite oxide, in the absence of solvent, with crystalline packaging supported by C–H…N C–H…π interactions. According frontier molecular orbitals, ...

A series of new benzimidazole derivatives with potential anticancer activity were tested as a new topoisomerase I inhibitors. The fluorometric method was used to determine in vitro the quantitative level of plasmid DNA relaxation by these compounds. Optimization of the fluorometric system and validation of the established analytical method were performed. Out of benzimidazole derivatives which ...

In the title compound, C24H18ClN3O2, the benzimidazole plane is nearly perpendicular to the phenyl ring and to the isoxazole ring, making dihedral angles of 75.95 (7) and 73.04 (8)°, respectively, but the two residues point in opposite directions with respect to the benzimidazole plane. The dihedral angle between the chloro-phenyl and isoxazole rings is 7.95 (8)°. In the crystal, mol-ecules are...

In the title compound, C(20)H(14)N(4), the dihedral angles between the central benzene ring and the pendant benzimidazole ring systems are 46.60 (15) and 47.89 (16)°. The dihedral angle between the benzimidazole ring systems is 85.62 (12)° and the N atoms lie to the same side of the mol-ecule. In the crystal, mol-ecules are linked by C-H⋯N inter-actions and weak aromatic π-π stacking [shortest ...

The mol-ecule of the title compound, C(26)H(18)N(4), resides on a crystallographic inversion centre with a dihedral angle of 44.94 (5)° between the benzimidazole ring system and the benzene ring. The primary hydrogen bond is C-H⋯N and inversion-related pairs of these generate a chain of rings along the c-axis direction; π⋯π stacking involving the benzimidazole groups with inter-planar separatio...

in this article, simple, convenient synthesis of 2-aryl-1-arylmethyl-1h-1,3-benzimidazole (1,2-disubstitutedbenzimidazoles) via condensation of 1,2-phenylenediamine and aromatic aldehydes using sba-pr-so3h as a nanoporous solid acid catalyst in green protocol was reported.

The Front Cover shows that compound 9a (in golden rod sticks), the benzimidazole bioisoster of azobenzene-containing BET inhibitor MS436, preferentially binds to first (BD1, in orange red) over second (BD2, slate blue) bromodomain family members. In this study, bioisosteric replacement azobenzene moiety selective inhibitors with a ring afforded set benzimidazole-6-sulfonamides. Evaluation bindi...