An enzyme is present in extracts of guinea pig polymorphonuclear leukocytes which can catalyze the hydrolysis of pyridine nucleotides. The enzyme is equally active toward nicotinamide adenine dinucleotide (NAD) or NAD phosphate, has an acid pH optimum, and is inhibited by either nicotinamide or isonicotinic acid hydrazide. This enzyme might be involved in the regulation of the pyridine nucleoti...

It has been shown previously that kynurenine hydrolase (L-kynurenine hydrolase, EC 3.7.1.3) is inhibited by the hydrazide Benserazide {R,, 4-4602, DL-serine 2-[(2,3,4trihydroxyphenyl)methyl] hydrazide), a compound that is used clinically in the treatment of Parkinson’s disease (Bender et al., 1977). Benserazide is a potent inhibitor of aromatic amino acid decarboxylase (L-aromatic amino acid ca...

Heparin, carboxy-group-reduced heparin, several sulphated monosaccharides and disaccharides formed from heparin, and a tetrasaccharide prepared from chondroitin sulphate were treated at 100 degrees C with hydrazine containing 1% hydrazine sulphate for periods sufficient to cause complete N-deacetylation of the N-acetylhexosamine residues. Under these hydrazinolysis conditions both the N-sulphat...

A series of linear and macrocyclic peptides 3-12 were synthesized using 3,5-pyridinedicarboxylic acid (1) as starting material and screened for their antimicrobial, anti-inflammatory and anticancer activities. Bis-ester 3 was prepared from 1 and L-leucine methyl ester. Hydrazinolysis and hydrolysis of dipeptide methyl ester 3 with hydrazine hydrate or 1 N sodium hydroxide afforded compounds 4 a...

Eight new complexes of Cu(II), Co(II), Ni(II) and Zn(II) with isonicotinic acid hydrazide (isoniazid, (INH)) and isonicotinic acid (1-naphthylmethylene)hydrazide (INNMH), having the formula of the type [M(INH)(ac)2] or [M(INNMH)(ac)2] (M = Co(II), Ni(II) and Zn(II)) and [Cu(INH)(ac)2]2, [Cu(INNMH)(ac)2]2, were synthesized and characterized. All complexes were characterized based on elemental an...

A bidentate ligand derived from furan-2-aldehyde and nicotinic acid hydrazide was characterized through analytical and spectral studies. Mn(II), Co(II), Cu(II) and Zn(II) complexes of nicotinic acid furan-2-ylmethylene-hydrazide have been synthesized and characterized by molar conductance, elemental analysis, UV-Vis, IR, H NMR, C NMR and ESR studies. The above studies confirm the electrolytical...

and y-glutamylhydrazides effectively. The pure hydrazide was converted into the azide in chloroform solution and coupled in one experiment with L-alanine methyl ester and in another with diethyl L-glutamate, according to the procedure ofLe Quesne & Young (1950b). The products were saponified with N-NaOH, and after acidification the acids were extracted into ethyl acetate, which, after drying (N...