نتایج جستجو برای: bedaquiline
تعداد نتایج: 462 فیلتر نتایج به سال:
Abstract Background Drug-resistant tuberculosis (DR-TB) remains a major public health concern worldwide. Bedaquiline, novel diarylquinoline, was added to the WHO-recommended all-oral regimen for patients with multidrug-resistant tuberculosis. We performed systematic review and meta-analysis determine effect of bedaquiline on treatment outcomes. Methods searched PubMed, Web Science EMBASE databa...
A woman with extremely drug-resistant tuberculosis treated with a drug regimen including linezolid and bedaquiline during her last 3 weeks of pregnancy gave birth to a child without abnormalities. No fetal toxicities were noted by 2 years after delivery. This drug combination might be safe during the late third trimester of pregnancy.
A rapid sensitive and accurate method for the quantitative qualitative estimation of bedaquiline was developed using reverse phase HPLC (RP HPLC) acetonitrile 0.1% trifluoroacetic acid as mobile phase. The system’s suitability established. validated per ICH guidelines. system established with a good resolution peak retention time 2.27min. linearity at 242nm in range 30-180µg/ml, correlation cor...
some patients (as in our case) clofazimine represents the only effective drug, exclusion of clofazimine from salvage therapy would greatly limit treatment efficacy. Patients due to receive a regimen with QT prolonging drugs (i.e. bedaquiline, delamanid, clofazimine and moxifloxacin) alone or in combination should receive ECG and electrolytes monitoring before and during treatment, so as not to ...
We report the experiences of 5 patients taking bedaquiline with delamanid in combination: 1 patient was cured; 3 culture converted, with 2 continuing and 1 changing therapy; and 1 died from respiratory insufficiency. For 2 patients, QT-interval prolongation but no arrhythmias occurred. Use of this therapy is justified for patients with limited options.
We report 20 cases of extensively drug-resistant tuberculosis managed in France. Treatment was individualized and included bedaquiline and linezolid for most patients and surgery in 8 patients. At last follow-up (22 months), 19 patients had achieved conversion from positive to negative on culture testing. These promising results of comprehensive management obtained in a small series deserve con...
A number of inhibitors of the essential Mycobacterium tuberculosis mycolic acid transporter, MmpL3, are currently under development as potential novel antituberculosis agents. Using the checkerboard method to study the interaction profiles of various antituberculosis drugs or experimental compounds with two different chemotypes inhibiting this transporter (indolcarboxamides and adamantyl ureas)...
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