I write in response to the article by Al Jarad et al on this topic. The first study to compare the eYcacy of BCG vaccination and its side eVects using the Bignal multipuncture device with the reusable handle and disposable heads was the pilot study of neonatal BCG vaccination carried out in 1992 for the Department of Health in our health authority. In previous studies in neonates and children u...

I write in response to the article by Al Jarad et al on this topic. The first study to compare the eYcacy of BCG vaccination and its side eVects using the Bignal multipuncture device with the reusable handle and disposable heads was the pilot study of neonatal BCG vaccination carried out in 1992 for the Department of Health in our health authority. In previous studies in neonates and children u...

Mycobacterium bovis BCG is widely used as a vaccine against tuberculosis (TB), despite its variable protective efficacy. Relatively little is known about the immune response profiles following BCG vaccination in relation to protection against TB. Here we tested whether BCG vaccination results in immune responses to DosR (Rv3133c) regulon-encoded proteins. These so-called TB latency antigens are...

In both humans and animals, controversy exists concerning the duration of protection induced by BCG vaccine against tuberculosis (TB) and whether revaccination enhances protection. A long-term study was undertaken to determine whether BCG-vaccinated calves would be protected against challenge with Mycobacterium bovis 2½ years after vaccination and to determine the effect of revaccination after ...

I write in response to the article by Al Jarad et al on this topic. The first study to compare the eYcacy of BCG vaccination and its side eVects using the Bignal multipuncture device with the reusable handle and disposable heads was the pilot study of neonatal BCG vaccination carried out in 1992 for the Department of Health in our health authority. In previous studies in neonates and children u...

Dr. L. Misery, Dr. P. Combemale, Service de Dermatologie, HIA Desgenettes, Boulevard Pinel, F-69003 Lyon (France) We have seen unusual adverse reactions to BCG vaccination in a 21-year-old man with personal and familial atopy. There was no history of tuberculosis nor exposure to individuals with known tuberculosis. BCG vaccination was performed because his tuberculin test was negative. One mont...

INTRODUCTION Bacille Calmette-Guerin (BCG) vaccination remains a routine immunization in primary care in tuberculosis (TB)-endemic areas, though several studies found that its efficacy was inconclusive. Natural resistance-asociated machrophage protein 1 (NRAMP1) polymorphism has been shown to result in higher susceptibility to TB. Information on genetic susceptibility in populations will be use...

BACKGROUND The Manchester Community Asthma Study (MANCAS) found a protective effect against the risk of wheeze at age 6 to 11 years for children given neonatal BCG vaccination. Our subsequent systematic review and meta-analysis suggested that BCG vaccination did not protect against allergic sensitization but might have exerted a protective effect against nonatopic asthma. OBJECTIVES We sought...

BCG vaccination of neonatal calves induces significant protection against bovine tuberculosis. The enhanced protection observed in neonatal calves may be linked to an enhanced capacity for IFNgamma production by innate cells, including WC1(+) gammadelta T cells, which constitute a major population in young cattle. Intranasal BCG vaccination of mice induces high levels of IFNgamma in the lungs, ...

Information from comparative proteome analysis of Mycobacterium tuberculosis and Mycobacterium bovis bacillus Calmette-Guerin (BCG) principally allows prediction of potential vaccine candidates. Thirty-six M. tuberculosis DNA vaccine candidates identified by comparative proteome analysis were evaluated in the mouse model for protection against low-dose aerosol M. tuberculosis infection. We iden...