The demonstration that epithelial cells of mouse and rat synthesize basement membrane antigens in tissue culture has established the concept that epithelia in general synthesize basement membrane (Pierce et al., 1964; Pierce and Nakane, 1967). Epithelial basement membranes contain hydroxyproline (Mukerjee et al., 1965). In addition, these membranes contain antigens shared by collagen and other ...

Age-related increases in basement membrane thickness have been noted in many tissues, including the testis. The current investigation examined the morphology of the basement membrane in the aged Brown Norway rat and sought to determine whether the accumulation of basement membrane was the result of an increase in the expression of the basement membrane genes. The aged testis was characterized b...

Arterial basement-membrane-like material was isolated from rabbit aortic myomedial cell cultures by sonication and differential centrifugation. Isolated basement-membrane-like material was shown to be free of both cellular and matrix contaminants, on the basis of determinations of DNA, RNA, cholesterol, phosphorus and (Na+ + K+)-activated ATPase, combined with electron microscopy. Amino acid an...

The basement membrane components in the primary and metastatic lesions of 29 cases of early gastric cancer were histologically and immunohistochemically examined. On silver-impregnated specimens, reticular fibers were much more abundant in the basement membrane regions and stromal tissues in the metastatic lesions than in the primary lesions. Immunohistochemically, the basement membrane compone...