Introduction: Klotho and dipeptidyl peptidase-4 (DPP4) are two proteins that modulate inflammatory pathways. We investigated the association between circulating klotho and DPP4 activity and their relationship with inflammatory cytokines, miR-29a, and miR-195 in Alzheimer disease (AD). Methods: This study was conducted on 16 AD patients and 16 healthy age-matched controls. Plasma levels of tumo...

alzheimer’s disease (ad) is the most common cause of dementia caused by complicated interactions between genetic and environmental factors. molecular genetic research has provided valuable information regarding the genetic etiology of the disease. identifying the genetics of ad not only could shed light on disease pathogenesis, but it may also provide potential targets for effective treatment, ...

introdouction: the purpose of the present study was to determine the possible relationship between gonial angle size and three mandibular morphometric parameters, namely, panoramic mandibular index (pmi), mandibular cortical width (mcw), and antegonial notch depth (ad), in digital panoramic radiographs. materials and methods: pmi, mcw, and ad were calculated in digital panoramic radiographs of ...

background: alzheimer’s disease (ad) is the most common type of dementia. demonstrating the modifiable risk factors of ad can help to plan for prevention of this disease. the aim of the current review was to characterize modifiable cardiovascular risk factors of ad using existing data and determine their contribution in ad development in iran and the world. methods: the systematic search was do...

Introdouction: The purpose of the present study was to determine the possible relationship between gonial angle size and three mandibular morphometric parameters, namely, panoramic mandibular index (PMI), mandibular cortical width (MCW), and antegonial notch depth (AD), in digital panoramic radiographs. Materials and methods: PMI, MCW, and AD were calculated in digital panoramic radiographs of...

Metacognitive awareness has been shown to be a critical skill for academic success. However, students often struggle to regulate this ability during learning tasks. The current study investigates how features designed to promote metacognitive awareness can be built into the game-based intelligent tutoring system (ITS) iSTART-2. College students (n=28) interacted with iSTART-2 for one hour, comp...

Introduction: Alzheimer disease (AD) is the most common form of dementia worldwide. The modalities to diagnose AD are generally expensive and limited. Both the central nervous system (CNS) and the retina are derived from the cranial neural crest; therefore, changes in retinal layers may reflect changes in the CNS tissue. Optical coherence tomography (OCT) machine can show delicate retinal layer...

Alzheimer is age-related, progressive brain degeneration disease. It destroys memory slowly. The number of people living with AD is increasing as fast as the count of aged population and extension of bad nutrition habits. The main cause of AD is not clearly known, but prior studies noted the importance of inflammation in Tau hyperphosphorylation and failure of microglia to clear AB peptide accu...

Background: Alcohol dependence (AD) is a major reason for morbidity and visits to emergency medical settings. However, the detection of AD is often difficult or overlooked. This study aimed to develop a brief screening questionnaire in Hindi language for detection of AD in an emergency medical setting. Methods:  The authors in consultation devised a set of questions related to AD in the Hindi l...