BACKGROUND Generation of membrane curvature is critical for the formation of plasma membrane protrusions and invaginations and for shaping intracellular organelles. Among the central regulators of membrane dynamics are the BAR superfamily domains, which deform membranes into tubular structures. In contrast to the relatively well characterized BAR and F-BAR domains that promote the formation of ...

The dimensional synthesis is done by using Genetic Algorithm to achieve a desired trajectory. Three problems are analyzed having different curvature. The program is authored in MATLAB ® 2010a. The error is seen to be in the permissible prescribed limit. The prototyping of straight line trajectory analysis is also done in ADAMS ® .

Passive linkages were developed to improve grasp functionality and minimize a prosthetic terminal device's number of user-controlled inputs. The linkages act to stabilize grasped objects and substitute for the palp of normal anatomical fingers. The Southampton Hand Assessment Procedure was used to compare the normal anatomical hand, this prototype, and a commercially available (Hosmer) hook. In...

This paper concentrates on the application of fuzzy logic based on Taguchi method (FLTM) for multiobjective optimization of the small-length flexural pivot (belongs to link 4) in partially four bar-compliant mechanisms. The input parameters such as the input torque and the crank angle of link 2 were optimized with considerations of the multiple performance measures as angular displacement and s...

In this paper, some definitions and traditional formulas for calculating the mobility of mechanisms are represented, e.g. Grubler formula, Somov - Malyshev formula, and Buchsbaum - Freudenstei. It is discussed that there are certain cases in which they are too ambiguous and incorrect to use. However, a matrix method is suggested based on the rank of the Jacobian of the mechanism and its applica...

Endophilin-A1 is a BAR domain-containing protein enriched at synapses and is implicated in synaptic vesicle endocytosis. It binds to dynamin and synaptojanin via a C-terminal SH3 domain. We examine the mechanism by which the BAR domain and an N-terminal amphipathic helix, which folds upon membrane binding, work as a functional unit (the N-BAR domain) to promote dimerisation and membrane curvatu...

Eukaryotic cells are defined by extensive intracellular compartmentalization, which requires dynamic membrane remodeling. FER/Cip4 homology-Bin/amphiphysin/Rvs (F-BAR) domain family proteins form crescent-shaped dimers, which can bend membranes into buds and tubules of defined geometry and lipid composition. However, these proteins exhibit an unexplained wide diversity of membrane-deforming act...

In this study, an expert system was developed for a quadricycle four bar mechanism with control of transmission angle. Different types of available synthesis methods are studied and the suitable synthesis procedure is selected for developing the expert system.

Linkage mechanisms are perhaps the simplest mechanical structures in engineering, but they can exhibit significant nonlinearity which can in principle be exploited. In this paper a simple smart structure model is developed based on such nonlinearity to investigate the reconfiguration of a four-bar mechanism through phase space connections. The central idea is based on heteroclinic connections i...