a potent new luteinising hormone-releasing hormone agonist Zoladex (ICI 118630) in a phase I clinical trial. On progression of disease 26 patients have undergone therapeutic oophorectomy. We present the clinical and endocrinological responses to treatment in 45 assessable patients. The response rate to Zoladex in this series was 31% and the ER status of the primary tumour was predictive of a re...

In Drosophila, heterozygosity in the pro-apoptotic gene hid significantly reduces apoptosis that is induced by ionizing radiation (IR). Therefore, mechanisms that regulate Hid levels can potentially contribute to life-or-death decision of an irradiated cell. 3'UTR of hid mRNA contains 5 potential binding sites for bantam microRNA. Ectopic expression of ban attenuated apoptosis that results from...

Since the ban gene of bacteriophage P1 suppresses a number of conditionally lethal dnaB mutations in Escherichia coli, it was assumed that Ban protein is a DNA helicase (DnaB analogue) that can substitute for DnaB in the host replication machinery. We isolated and sequenced the ban gene, purified the product, and analysed the function of Ban protein in vitro and in vivo. Ban hydrolyses ATP, unw...

Introduction: Gutkha contains harmful and carcinogenic chemicals and oral cancer caused by tobacco usage has been reported as a major preventable cause of death worldwide by the World Health Organization. The Telangana state government implemented a ban on gutkha usage starting in 2013 but how effective this ban has been remains unclear. Objectives: The objective of this study was to determine ...

Newcastle disease virus (NDV) can cause severe disease in chickens. Although NDV vaccines exist, there are frequent reports of outbreaks in vaccinated chickens. During 2009-2010, despite intense vaccination, NDV caused major outbreaks among commercial poultry farms in Indonesia. These outbreaks raised concern regarding the protective immunity of current vaccines against circulating virulent str...

Body Area Networks (BAN) can provide a wide range of applications including medical support, healthcare monitoring, and consumer electronics with increased convenience or comfort. To harmonize with the strong demands from both medical and healthcare societies, and information and communications technology (ICT) industries, IEEE 802.15.6 task group (TG6) was set up to develop an IEEE wireless st...

BACKGROUND Nebulized drug delivery is a cornerstone of therapy for obstructive lung disease, but the ideal nebulizer design is uncertain. The breath-actuated nebulizer (BAN) may be superior to conventional nebulizers. This study compared the BAN to standard nebulizer with regard to efficacy, safety, and patient and respiratory therapist (RT) satisfaction. METHODS Adults admitted to the hospi...

At the University of Twente we have been researching mobile healthcare applications since 1999. Since 2002 the University of Twente and partners have been developing health Body Area Networks (BANs) and a BAN service platform. We define a BAN as a network of communicating devices worn on, around or in the body which provides mobile services to the user. The BAN may also communicate to remote us...

Like any self-respecting public health official, it was my lifelong dream to be sued by a tobacco company. I got my wish in 2008. At that time I was the Director of the San Francisco Department of Public Health, and we became the first locality to ban the sale of tobacco at pharmacies. Phillip Morris USA, Inc. promptly filed suit in the United States District Court to overturn the ban. Their la...