PHYSIOLOGY, BIOPHYSICS AND COMPUTATIONAL BIOLOGY Correction for “Direct visualization of the arterial wall water permeability barrier using CARS microscopy,” by Bertrand M. Lucotte, Chloe Powell, Jay R. Knutson, Christian A. Combs, Daniela Malide, Zu-Xi Yu, Mark Knepper, Keval D. Patel, Anna Pielach, Errin Johnson, Lyudmyla Borysova, Kim A. Dora, and Robert S. Balaban, which appeared in issue 1...

We developed and compared two mathematical models of variable phenotypic switching rates between normal and persister cells that depend on substrate concentration and antibiotic presence. They could be used to simulate the formation of persisters in environments with concentration gradients such as biofilms. Our models are extensions of a previous model of the dynamics of normal and persistent ...

Valence molecular connectivity indices are based on the concept of valence delta, δ v, that can be derived from general chemical graphs or chemical pseudographs. A general graph or pseudograph has multiple edges and loops and can be used to encode, through the valence delta, chemical entities. Two graph-theoretical concepts derived from chemical pseudographs are the intrinsic (I) and the electr...

A combined experimental and theoretical study of the absorption spectra of a group of closely related pyrylium perchlorates 1-11 are presented. Minor changes in the position of the substituents lead to drastic changes in the absorption spectra in this series of compounds. We have attempted to explain the observed changes using the x,y-band notation developed by Balaban and co-workers. Absorptio...

Organic compounds containing heteroatoms or multiple bonds can be conveniently represented as vertex- and edge-weighted molecular graphs. These atom and bond parameters can be computed for any organic compound with two parameter sets that we have recently defined, namely, the relative electronegativity X and the relative covalent radius Y weighting schemes. Structural descriptors computed with ...

AIM To assess the topographical relation between gastric glands, using the minimum spanning tree (MST), to derive both a model of neighbourhood and quantitative representation of the tissue's architecture, to assess the characteristic features of gastric atrophy, and to assess the grades of gastric atrophy. METHODS Haematoxylin and eosin stained sections from corporal and antral biopsy specim...

This work is aimed at describing the workflow for a methodology that combines chemoinformatics and pharmacoepidemiology methods and at reporting the first predictive model developed with this methodology. The new model is able to predict complex networks of AIDS prevalence in the US counties, taking into consideration the social determinants and activity/structure of anti-HIV drugs in preclinic...