As one of the most abundant RNA post-transcriptional modifications, N6-methyladenosine (m6A) involves in a broad spectrum of biological and physiological processes ranging from mRNA splicing and stability to cell differentiation and reprogramming. However, experimental identification of m6A sites is expensive and laborious. Therefore, it is urgent to develop computational methods for reliable p...

High capacity Last Level Cache (LLC) architectures have been proposed to mitigate the widening processor-memory speed gap. These LLC architectures have been realized using DRAM or SpinTransfer-Torque Random Access Memory (STT-RAM) memory technologies. It has been shown that STT-RAM LLC provides improved energy efficiency compared to DRAM LLC. However, existing STT-RAM LLC suffers from increased...

To enable the design of large capacity memory structures, novel memory technologies such as non-volatile memory (NVM) and novel fabrication approaches, e.g., 3D stacking and multi-level cell (MLC) design have been explored. The existing modeling tools, however, cover only a few memory technologies, technology nodes and fabrication approaches. We present DESTINY, a tool for modeling 2D/3D memori...

The Virtual Generalizing Random Access Memory Weightless Neural Network (VGRAM WNN) is a type of WNN that only requires storage capacity proportional to the training set. As such, it is an effective machine learning technique that offers simple implementation and fast training – it can be made in one shot. However, the VG-RAM WNN test time for applications that require many training samples can...

OBJECTIVE Autopsy cases show that cortical lesions (CLs) in multiple sclerosis (MS) lack lymphocyte/macrophage influx, blood-brain barrier breakdown, and complement activation. However, some CLs were demonstrated to harbor activated microglia. Here, we assessed the clinical significance of microglia activation in CLs in a large autopsy sample, and we investigated possible interrelationships wit...

BACKGROUND AND OBJECTIVE Skeletal muscle has been suggested as an important factor in the pathophysiology of metabolic syndrome. During the aging process, muscle mass is lost in specific body parts. However, few studies have investigated the relationship between site-specific muscle loss assessed using computed tomography (CT) and metabolic syndrome. This study was conducted to investigate the ...

1 Department of Arctic and Marine Biology, UiT The Arctic University of Norway, Tromsø, Norway, 2 Fram Centre, Norwegian Polar Institute, Tromsø, Norway, 3 Fram Centre, Akvaplan-Niva, Tromsø, Norway, 4 Department of Marine Sciences Tjärnö, University of Gothenburg, Strömstad, Sweden, 5 Department of Arctic Biology, University Centre on Svalbard, Longyearbyen, Norway, 6 Department of Global Chan...

During May 1988 a 1230-m ice thickness profile was drilled across a floe in Fram Strait. The probability density function of this data set corresponds closely to extensive ice draft measurements from submarines and the thickness distribution of floes sampled randomly in the area. The observed similarity is attributed to the topography of the pack ice in Fram Strait where each floe is composed o...