BACKGROUND Due to increasing resistance development among bacteria, antimicrobial peptides (AMPs), are receiving increased attention. Ideally, AMP should display high bactericidal potency, but low toxicity against (human) eukaryotic cells. Additionally, short and proteolytically stable AMPs are desired to maximize bioavailability and therapeutic versatility. METHODOLOGY AND PRINCIPAL FINDINGS...

PURPOSE To evaluate the effect of conditioned medium from human uterine cervical stem cells (CM-hUCESCs) on corneal epithelial healing in a rat model of dry eye after alkaline corneal epithelial ulcer. We also tested the bactericidal effect of CM-hUCESCs. METHODS Dry eye was induced in rats by extraocular lacrimal gland excision, and corneal ulcers were produced using NaOH. Corneal histologic...

The effects of teicoplanin (8 micrograms/ml), ampicillin (64 micrograms/ml), imipenem (32 micrograms/ml), and gentamicin (4 micrograms/ml), alone and in combination, against 13 unique blood isolates of vancomycin-resistance (MIC for 90% of isolates tested [MIC90], 512 micrograms/ml), teicoplanin-susceptible (MIC90, 2.0 micrograms/ml), ampicillin-resistant (MIC90, 128 micrograms/ml), and non-bet...

in  this  reaserch,  photocatalyst  titanium  dioxide  was  doped  with silver  and modified  by  polyethylene  glycol  by  sol  gel method  and the  samples  were  characterized  by  x-ray  diffraction  (xrd)  and scanning  electron  microscopy  (sem).  the  purpose  of  the  present study  was  to  evaluate  the  photocatalytic  bactericidal  effects  of prepared nanocomposite on human pathog...

Mezlocillin is subject to dose-dependent pharmacokinetics. Previous studies have examined the pharmacokinetic but not the pharmacodynamic aspects of this effect. The pharmacokinetic disposition of mezlocillin was determined in eight healthy volunteers in a randomized, crossover fashion after single infusions of 50 and 80 mg of mezlocillin per kg of body weight. Plasma and urine were assayed wit...

The rise of antimicrobial resistance as a pressing global healthcare challenge underscores the need to identify novel strategies tackle pathogenic bacteria. Many naturally occurring nanostructures exhibit an innate ability deactivate bacterial cells by physical contact. However, several aspects underlying mechanisms are poorly understood due complex interactions with nanostructures, which diffi...

Lactoperoxidase catalyzes the oxidation of thiocyanate by hydrogen peroxide into hypothiocyanite, a reaction which can protect bacterial and mammalian cells from killing by hydrogen peroxide. The present study demonstrates, however, that lactoperoxidase in the presence of thiocyanate can actually potentiate the bactericidal and cytotoxic effects of hydrogen peroxide under specific conditions, s...

Virulent isolates of Vibrio vulnificus resist the bactericidal and opsonizing effects of normal human serum, in contrast to environmental isolates, which are highly serum susceptible. Immune responses to bacteremic V. vulnificus infections in human subjects have not been characterized. Serum from a patient who survived sepsis caused by V. vulnificus had substantial bactericidal and opsonizing i...

Strontium-releasing injectable bone cements may have the potential to prevent implant-related infections through the bactericidal action of strontium, while enhancing bone formation in patients suffering from osteoporosis. A melt-derived bioactive glass (BG) series (SiO2–CaO–CaF2–MgO) with 0–50% of calcium substituted with strontium on a molar base were produced. By mixing glass powder, poly(ac...

recently, the effects of antimicrobial activity of silver nanoparticles was considered by researcher because of bacterial resistance to antimicrobial agents in chemical.the aim of this study was to evaluate the antimicrobial activity of the gold nanoparticles on escherichia coli. gold nanoparticles are chemically synthesized. standard strain of e. coli was cultured in a nutrient broth. minimum ...