This comprehensive review summarizes the mechanism of action, pharmacokinetics, efficacy, and safety of besifloxacin ophthalmic suspension, 0.6% and examines its role in the treatment of ocular surface bacterial infections. Besifloxacin possesses balanced activity against bacterial topoisomerase II (also called DNA gyrase) and topoisomerase IV. It has shown a low potential to select for bacteri...

Conjunctivitis is the commonest eye disease in Egypt, where it presents a major problem of public health. The chief menace of acute infective conjunctivitis lies in the corneal complications which may cause blindness. Since the late 1930s, the gonococcus and KochWeeks bacillus have been regarded as the most common causes of this condition in Egypt (Wilson, I935; Lyons and Amies, I949), but othe...

OBJECTIVES To identify the etiological agent in bacterial conjunctivitis and to determine the antibiogram of bacterial isolates. METHODOLOGY This observational study was conducted at Dr. Essa's Laboratory over a period of 12 months ending in March 2012. Two hundred samples taken from conjunctiva of patients with conjunctivitis were cultured on routine medium and the antibiograms of bacterial ...

G.S. 2989 Hcl (Pfizer) is a new tetracycline derivative without any generic name. In a cinico-cytological study by Nema, Nath, Bal, and Shukla (1964) on 48 trachomatous cases treated by G.S. 2989 Hcl (025 per cent. in oil) the antibiotic was found quite effective against trachoma and associated bacterial conjunctivitis. It was observed that the drug could produce 66-7 per cent. cure of trachoma...

A survey of the management of eye disease in the community was carried out in two general practices over a three-month period. During this time there were 238 consultations by patients with ocular symptoms, making up 2.3% of all consultations and giving an annual consultation rate for eye disease of 66 per 1000 persons at risk. The four commonest diagnoses were bacterial conjunctivitis, allergi...

PURPOSE To compare the clinical and bacteriological effects of fucidic acid (Fucithalmic: 1.0%) and chloramphenicol (Minims(R): 0.5%) eye drops in neonates with a clinical diagnosis of acute conjunctivitis of suspected bacterial origin. METHODS A TOTAL OF 456 N: ewborns with gestational age > 32 weeks with acute conjunctivitis of suspected bacterial origin acquired within the first 28 days of...

QUESTION In my office I occasionally see neonates with conjunctivitis. What are the current recommendations for ocular prophylaxis at birth? Do topical antibiotics alone provide adequate treatment of neonatal conjunctivitis? When is systemic therapy indicated? ANSWER All infants should receive ocular prophylaxis at birth to prevent gonococcal ophthalmia. Neonates presenting with signs of conj...

PURPOSE To compare the safety and tolerability of 1.0% azithromycin in a polymeric mucoadhesive delivery system with 0.3% tobramycin ophthalmic solution for the treatment of bacterial conjunctivitis. METHODS This study was a prospective, randomized, active-controlled, double-masked, phase 3 trial conducted from August 6, 2004, to October 6, 2005, at 47 sites. Subjects with a clinical diagnosi...