نتایج جستجو برای: bacterial barrier

تعداد نتایج: 291925  

Journal: :Proceedings of the National Academy of Sciences 1993

2017
Ishan Ghai Shashank Ghai

One of the main fundamental mechanisms of antibiotic resistance in Gram-negative bacteria comprises an effective change in the membrane permeability to antibiotics. The Gram-negative bacterial complex cell envelope comprises an outer membrane that delimits the periplasm from the exterior environment. The outer membrane contains numerous protein channels, termed as porins or nanopores, which are...

Journal: :American journal of physiology. Lung cellular and molecular physiology 2001
K A Mohammed N Nasreen J Hardwick C S Logie C E Patterson V B Antony

Pneumonia remains one of the most common infectious causes of mortality. Patients with pneumonia develop parapneumonic effusions with a high neutrophil count as well as high protein concentrations. We hypothesized that pulmonary parenchymal bacterial infection causes a permeability change in the pleural mesothelium by inducing the production of vascular endothelial growth factor (VEGF). Complic...

Journal: :The Journal of clinical investigation 2015
Brandon J Kim Bryan M Hancock Andres Bermudez Natasha Del Cid Efren Reyes Nina M van Sorge Xavier Lauth Cameron A Smurthwaite Brett J Hilton Aleksandr Stotland Anirban Banerjee John Buchanan Roland Wolkowicz David Traver Kelly S Doran

Bacterial meningitis is a serious infection of the CNS that results when blood-borne bacteria are able to cross the blood-brain barrier (BBB). Group B Streptococcus (GBS) is the leading cause of neonatal meningitis; however, the molecular mechanisms that regulate bacterial BBB disruption and penetration are not well understood. Here, we found that infection of human brain microvascular endothel...

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