PURPOSE Cholestatic liver injury is associated with a high production of free radicals. The pathogenesis of liver injury in biliary atresia (BA) patients is largely undefined. The goal of the present study was to clarify the oxidative damage and the changes in antioxidant enzyme activities that occur during the development of BA and after liver transplantation (LT). METHODS We enrolled BA pat...

BACKGROUND Betulinic acid (BA) is a lupane-type triterpene which has been considered as a promising agent to cure melanoma with no side effects. Considering that BA is naturally produced in small quantities in plants, we previously reported the success in engineering its production in yeast. In the present study, we attempted to improve BA biosynthesis in yeast by the use of different strategie...

0.094 ----TSB 37°C Baciillus sp. Clone 35 23 0.047 ----TSB 37°C Bacillaceae bacterium C22 21 1.7 ----BA 37°C Bacillus cereus 43 0.75 ----BA 30°C 38 0.5 ----TSB 30°C Bacillus fusiformis 14 1.5 ----BA 37°C Bacillus aquimaris 45 1.2 CXM30 4.25mm BA 30°C Bacillus pumilus 48 3.5 ----R2A 37°C Bacillus megaterium 32 0.064 ----BA 30°C 42 0.75 ----TSB 37°C 19 0.25 ----TSB 30°C 18 0.38 CXM30 1.75mm LB 37°C

Fig. 6 Effects of BA upon hepatic inflammation, determined by H&E stain, in mice with BA at 0, 0.05 or 0.1% for 4 weeks, and followed by APAP treatment. Normal groups had neither BA nor APAP treatments. BA groups had 0.1% BA intake without APAP treatment. Ishak inflammation score was used to quantify the injury area. Values are mean ± SD, n = 10. A representative image is shown for each group. ...

BACKGROUND AND PURPOSE Numerous studies have shown that cerebral vasospasm is one of the leading causes of death and neurological disability after subarachnoid hemorrhage. Most of these studies, however, have focused on anterior circulation vessels. Since the introduction of the transcranial Doppler (TCD), increasing attention has been given to basilar artery (BA) vasospasm, especially in traum...

This study presents biodegradation of benzoic acid (BA) and anthranilic acid (AA) by Micrococcus sp. under aerobic conditions. Initial concentrations of BA and AA were varied (500-2500 mg/l) and almost complete biodegradation of BA and AA was observed within 30 h. Andrews kinetic model for single substrate was fitted to obtain maximum specific growth rates, half saturation and substrate inhibit...

Phaseolus vulgaris L. plants were supplied through the root with [8-(14)C]benzylaminopurine ([(14)C]BA). Collections of root, apex, and leaves were made 8 and 48 hours after labeling; ethanolic extracts of tissues were purified and subjected to thin layer chromatography on silica gel and/or cellulose powder.From [(14)C]BA at least two different metabolites originate, the BA riboside and ribotid...

Butyric acid (BA) induces cytodifferentiation in vitro of a wide variety of neoplastic cells. The potential clinical utility of BA is limited by the apparent difficulty of achieving effective concentrations because of its rapid metabolism and short plasma half-life. In this study we addressed two approaches that may achieve effective concentrations of BA in vivo. One strategy is to use BA deriv...

Objective This study proposed a modified Blumgart anastomosis (m-BA) that uses a firm ligation of the main pancreatic duct with a supporting tube to replace the pancreatic duct-to-jejunum mucosa anastomosis, with the aim of simplifying the complicated steps of the conventional BA (c-BA). Thus, we observe if a difference in the risk of postoperative pancreatic fistula (POPF) exists between the t...

INTRODUCTION As cost considerations become increasingly critical when selecting optimal endovascular treatment strategies, a cost-benefit analysis was conducted comparing the Diamondback 360°® Orbital Atherectomy System (OAS) (Cardiovascular Systems, Inc., St Paul, MN, USA) and balloon angioplasty (BA) vs BA alone for treatment of calcified femoropopliteal lesions. PATIENTS AND METHODS The cl...