viral myocarditis is a common cardiovascular disease, which has greatly threatened human health. however, up to now, the pathogenesis of viral myocarditis has been unclear, which leads to the lack of its effective treatments. to investigate the role of chemokines in pathogenesis of viral myocarditis, mrna expression for a panel of 19 chemokines detected by rt-pcr in myocardial tissue of balb/c ...

The four encapsidated RNAs of brome mosaic virus (BMV; B1, B2, B3, and B4) contain a highly conserved 3' 200-nucleotide (nt) region encompassing the tRNA-like structure (TLS) which is required for packaging in vitro (Y. G. Choi, T. W. Dreher, and A. L. N. Rao, Proc. Natl. Acad. Sci. USA 99:655-660, 2002). To validate these observations in vivo, we performed packaging assays using Agrobacterium-...

Abstract 
 Moringa leaves (Moringa oleifera Lam) is one of the potential local feed ingredients broiler rations due to its nutrient contents such as carbohydrate (57,01%), crude protein (30,30%), fat (2,74%) well a source vitamin C, carotenoids and flavonoids. This study aimed determine effect using different levels Lam leaf meal (MOLM) in basal ration on plasma metabolites, including tota...

B3 is a tumor-reactive monoclonal antibody (mAb) that binds to a limited number of normal tissues. Immunotoxins made with B3 coupled to either Pseudomonas exotoxin (PE) or recombinant forms of PE with a deletion of the cell-binding domain (LysPE40) have been shown to cause complete tumor regression in nude mice bearing a rapidly growing A431 (L. H. Pai et al., Proc. Natl. Acad. Sci. USA, 88: 33...

The Gamma-aminobutyric acid (GABA) and glutamate (Glu) neurotransmitter systems are implicated in depression. While previous studies found reduced GABA levels, a tendency towards Glu, using proton (1H) magnetic resonance spectroscopy (1H-MRS), little is known about GABAA receptor availability Here, the aim was to characterize Glu-levels dorsal anterior cingulate cortex (dACC), whole-brain avail...

b3-Adrenoceptor agonists have recently been introduced for the treatment of overactive urinary bladder syndrome. Their target, the b3-adrenoceptor, was discovered much later than b1and b2-adrenoceptors and exhibits unique properties which make extrapolation of findings from the other two subtypes difficult and the b3-adrenoceptor a less-understood subtype. This article discusses three aspects o...

Introduction Lessons captured from interviews with 12 European regions are represented in a new instrument, the B3-Maturity Model (B3-MM). B3-MM aims to assess maturity along 12 dimensions reflecting the various aspects that need to be managed in order to deliver integrated care. The objective of the study was to test the content validity of B3-MM as part of SCIROCCO (Scaling Integrated Care in...

Increasing evidence suggests that AR (androgen receptor) acetylation is critical for prostate cancer cell growth. In the present study, we identified Pro-B3 (procyanidin B3) as a specific HAT (histone acetyltransferase) inhibitor. Pro-B3 selectively inhibited the activity of HATs, but not other epigenetic enzymes. Pro-B3 substantially inhibited the p300-mediated AR acetylation, both in vitro an...