A novel rare mutation, homeobox B13 (HOXB13) G84E, was reported to co-segregate with prostate cancer (PCa) in hereditary PCa families and associate with PCa risk in unrelated cases and controls. In this study, we aim to compare the G84E mutation frequency among subjects of different races/ethnicities from various geographic regions in the world and to assess its risk for developing PCa, in the ...

This study defines 10 epitopes by murine monoclonal antibodies, of which seven are new and three were previously defined by alloantibodies. Of particular interest, three antibodies reacted with almost all Bw4-associated antigens except that each was negative with one or two of the antigens. One was negative with B13, one negative with A25, and another negative with B13 & A24 antigens. These mon...

Dysfunction in the physiological pathways of programmed cell death may promote proliferation of malignant cells, and correction of such defects may selectively induce apoptosis in cancer cells. We measured the levels of ceramide, a candidate lipid mediator of apoptosis, in human metastatic colorectal cancer and tested in vitro and in vivo effects of various ceramide analogues in inducing apopto...

Isolated nucleoli from rat Novikoff hepatoma ascites cells incorporated 32P of [T-~~P]ATP into acid-soluble nucleolar proteins in vitro in systems containing 0.25 M sucrose, 5 mM MgCL, 12.5 mM NaCl, and 0.05 M Tris-HCl buffer (pH 7.3) at 37”. Although the total uptake of 32P reached a maximum after 15 min of incubation, the uptake into some protein bands increased with longer incubation times. ...

BACKGROUND HLA typing analysis is important in renal transplant patients. OBJECTIVES We made a plan to determine the most frequent HLA antigens in Iranian kidney transplant patients. PATIENTS AND METHODS In a retrospective cross sectional study, HLA patterns were defined in 512 kidney transplant recipients (67% male and 33% female) from different transplant centers of Tehran, Iran between 2...

The transformation of 3-chlorobenzoate (3CB) and acetate at initial concentrations in the wide range of 10 nM to 16 mM was studied in batch experiments with Pseudomonas sp. strain B13. Transformation rates of 3CB at millimolar concentrations could be described by Michaelis-Menten kinetics (K(infm), 0.13 mM; V(infmax), 24 nmol (middot) mg of protein(sup-1) (middot) min(sup-1)). Experiments with ...

Boron carbide phases exist over a widely varying compos-itional range B(12+x)C(3-x) (0.06 < x < 1.7). One idealized structure corresponds to the B(13)C(2) composition (space group R-3m) and contains one icosa-hedral B(12) unit and one linear C-B-C chain. The B(12) units are composed of crystallographically distinct B atoms B(P) (polar, B1) and B(Eq) (equatorial, B2). Boron icosa-hedra are inter...