Background We aimed to investigate the frequency of celiac disease in children with β-thalassemia major (B-TM) in Shiraz, southern Iran. Materials and Methods In this study, the prevalence of celiac disease in children with B-TM was evaluated. Children with BTM were screened for celiac disease by ant-tissue transglutaminase (anti-tTG) IgA antibody, IgA level and anti-tTG IgG. A total o...

OBJECTIVE To devise a strategy for prevention of beta thalassemia in newborns through reliable screening of indexed families. METHODS The cross-sectional study was conducted over six months in 2011 and comprised blood samples collected from subjects belonging to different ethnic groups from families of beta thalassemia major children registered with the Abbottonian Medical Association Blood C...

abstract background the purpose of this study was to assess the prevalence of major depressive and anxiety disorders in hemophilic and major beta thalassemic patients related to education of their mothers as a family’s agent. materials and methods a case-control study was performed on 34 major beta thalassemic patients. for each patient the control group was selected and matched (with age and s...

conclusions in patients with tm, bone widening, trabeculation, paraspinal masses and facial bone deformity were lower than patients with ti, whichcan be related to effectiveness of therapy with blood transfusion irrespective of its adverse effects in tm patients. results all radiologic findings were significantly higher in patients with ti compared to tm (p< 0.05). in patients with ti, only tra...

OBJECTIVE Alpha thalassemia syndromes are caused by mutations on one or more of the four α-globin genes. Mutations could be either more commonly deletional or non-deletional. As some deletions (3.7 and 4.2) cause α+-thalassemia, some cause (-20.5, MED, THAI, FIL) α0 -thalassemia. The aim of this study was to determine alpha thalassemia mutations in patients with unsolved hypochromic microcytic ...

background: beta-thalassemia major is one of the major health problems in our country. many studies have confirmed the fact that, these patients have an increased susceptibility to bacterial infections. objective: in this study, we have assessed the humoral immune system in 68 thalassemic patients by measuring their serum concentration of immunoglobulin g (igg), igm, iga, c3 and c4 in order to ...

Hemoglobinopathy and malaria are commonly found worldwide particularly in malaria endemic areas. Thalassemia, the alteration of globin chain synthesis, has been reported to confer resistance against malaria. The prevalence of thalassemia was investigated in 101 malaria patients with Plasmodium falciparum and Plasmodium vivax along the Thai-Myanmar border to examine protective effect of thalasse...

The recent transfer of Thalassemia Reports, the only journal fully dedicated on Thalassemia, from PagePress to MDPI was great news for those who contributed spread [...]

Thalassemia is a heritable human anemia caused by a variety of mutations that affect expression of the aor the b-chain of hemoglobin. The expressivity of the phenotype is likely to be inf luenced by unlinked modifying genes. Indeed, by using a mouse model of a-thalassemia, we find that its phenotype is strongly inf luenced by the genetic background in which the a-thalassemia mutation resides [1...

introduction : regular blood transfusions for patients with thalassemia major have improved their overall survival, but carry a definite risk of being infected with blood born viruses especially hepatitis b and c. nowadays, it has remained as main health concern about these patients. in this study, we tried to define the prevalence rate of hepatitis b and c and survey the related risk factors a...