1,5-benzodiazepines are regarded as one of the most important classes of heterocyclic compounds as privileged structures and have vast range of applications in the field of medicine and chemistry. they are therefore attractive synthetic targets for organic and medicinal chemist. the current review article mainly covers the multicomponent green chemistry approaches for the synthesis of 1,5-benzo...

this work described an efficient pseudo four-component synthesis of (10e)-n-benzylidene-2-phenylh-imidazo[1,2-a]pyridin-3-amine derivatives from 2-aminopyridin, malononitrile and arylaldehydes in the presence of naoh under solvent-free and conventional heating condition in good to excellent yields. a wide range of aromatic aldehydes would easily undergo condensations with 2-aminopyridin and mal...

normal 0 false false false en-us x-none ar-sa background: stroke is one of the most common causes of disabilities and death all over the world. the mortality rate of stroke is predicted to be doubled by 2030 in the middle east countries. nutrition is an effective strategy in prevention and management of stroke. this study assessed the relationship between various protein types and stroke risk. ...

introduction compartmental analysis allows the mathematical separation of tissues and organs to determine activity concentration in each point of interest. biodistribution studies on humans are costly and complicated, whereas such assessments can be easily performed on rodents. in this study, we aimed to develop a pharmacokinetic model of 153sm-maltolate complex as a novel therapeutic agent and...

with the aim to examine lead tolerance of populus nigra (clone 62/154) in symbiosis with arbuscular mycorrhizal fungi, a greenhouse experiment was carried out in a factorial randomized complete scheme with two factors 1) fungal inoculation in 4 levels (control, inoculation with glomus mosseae, inoculation with g. intraradices and inoculation with g. mosseae + g. intraradices) and 2) lead in 4 l...

basil (ocimum basilicum l.) belongs to the lamiaceae family as a medicinal plant used in traditional medicine in iran. the purpose of this test is to evaluate the effect of nano fe-chelate under salinity levels on the plant physiology and morphology characteristics. in this experiment  investigated the effect of nano fe-chelate and salinity stress on growth parameters, photosynthetic leaves rat...

normal 0 false false false en-us x-none ar-sa approximately 1% of all pregnancies are in woman with epilepsy. although, the majority of children born to women with epilepsy are normal, they are at increased risk for malformations. notably, the teratogenicity of antiepileptic drugs is a well-defined subject. the incidence of major malformations in offspring of mothers with epilepsy who were trea...

plant growth-promoting rhizobacteria (pgpr) is an alternative to chemical pesticides against harmful microorganisms especially soil-borne diseases. rhizoctonia solani is one of the most important soil-borne fungal pathogens that causes serious damages to important crops. in this study, to screen successful pseudomonas bacterial isolates, the inhibition of pathogen growth was evaluated in-vitro....

background: as we all know, sperm has the capacity to take up foreign dna, therefore, sperm mediated gen transfer can be an inexpensive and simple method in animal transgenesis in various species. however, there is not sufficient evidence of dna uptake by ovine spermatozoa. objectives: the purpose of the present study was to examine the uptake of human lysozyme gene contained plasmid (pegfp-ire...

background and objectives: soil salinity and zn deficiency are among the most important limiting factors for growth and yields of pistachio trees in many regions of iran, especially in the rafsanjan area. the use of plant growth promoting rhizobacteria (pgpr) is new strategies to reduce destructive effects of salinity and improvement of nutrient availability. this study investigated the interac...