Azure DocumentDB is Microsoft’s multi-tenant distributed database service for managing JSON documents at Internet scale. DocumentDB is now generally available to Azure developers. In this paper, we describe the DocumentDB indexing subsystem. DocumentDB indexing enables automatic indexing of documents without requiring a schema or secondary indices. Uniquely, DocumentDB provides real-time consis...

This study focuses on the understanding of the interaction of phenothiazinium dyes methylene blue (MB), new methylene blue (NMB), azure A (AZA) and azure B (AZB) with tRNAPhe with particular emphasis on deciphering the mode and energetics of the binding. Strong intercalative binding to tRNAPhe was observed for MB, NMB and AZB, bound by a partial intercalative mode. AZA has shown groove binding ...

Antimicrobial photodynamic inactivation (APDI) using phenothiazinium dyes is mediated by reactive oxygen species consisting of a combination of singlet oxygen (quenched by azide), hydroxyl radicals and other reactive oxygen species. We recently showed that addition of sodium azide paradoxically potentiated APDI of Gram-positive and Gram-negative bacteria using methylene blue as the photosensiti...

Cloud computing has emerged as one of the preferred platforms for on-demand, event-driven computing. However, literature on event-driven scientific modeling on the cloud is sparse. This paper presents our vision and architecture to provide a “Scientific Modeling as a Service”in an on-demand fashion. We choose one of the most widely used groundwater models, MODFLOW2000, from USGS to develop a Mo...

Second Harmonic Generation (SHG) has been used in combination with a near-field scanning optical microscope (NSOM) to image biological samples for the first time. Near-field SHG images of azure B stained mouse natural killer (NK) cells were recorded at four different wavelengths using a tunable near-infrared femtosecond laser. The surface specificity of SHG allows membrane structures to be sele...

Software industry is heading towards centralized computing. Due to this trend data and programs are being taken away from traditional desktop PCs and placed in compute clouds instead. Compute clouds are enormous server farms packed with computing power and storage space accessible through the Internet. Instead of having to manage one’s own infrastructure to run applications, server time and sto...