PURPOSE To determine and compare the shapes of the retinas of emmetropic and myopic eyes. METHODS Nonrotationally symmetrical ellipsoids were mathematically fitted to the retinal surfaces of 21 emmetropic and 66 myopic eyes (up to -12 D) of participants aged 18 to 36 years (mean, 25.5) using transverse axial and sagittal images derived from magnetic resonance imaging. RESULTS The shapes of ...

PURPOSE To determine whether the use of progressive addition spectacle lenses reduced the progression of myopia, over a 2-year period, in Hong Kong children between the ages of 7 and 10.5 years. METHODS A clinical trial was carried out to compare the progression in myopia in a treatment group of 138 (121 retained) subjects wearing progressive lenses (PAL; add +1.50 D) and in a control group o...

The lumican gene (lum), which encodes one of the major keratan sulfate proteoglycans (KSPGs) in the vertebrate cornea and sclera, has been linked to axial myopia in humans. In this study, we chose zebrafish (Danio rerio) as an animal model to elucidate the role of lumican in the development of axial myopia. The zebrafish lumican gene (zlum) spans approximately 4.6 kb of the zebrafish genome. Li...

PURPOSE To characterize the 24-hour change of intraocular pressure (IOP) in young adults with moderate to severe myopia. METHODS Nineteen young adults, ages 18 to 25 years, with moderate to severe myopia (myopia group) and 17 age-matched volunteers with emmetropia or mild myopia (control group) were housed for 1 day in a sleep laboratory. An 8-hour accustomed sleep period was assigned to each...

It has recently been reported that lid closure in monkeys, whether monocularly or binocularly performed, leads to an axial enlargement of the eye, resulting in a high myopia (Wiesel and Raviola, i?77. 1978). Using a similar experimental procedure in monkeys Von Noorden and Crawford (1978) were unable to repeat these results. Slight myopia was also obtained in tree shrews similarly operated. alt...

BACKGROUND/AIM To evaluate the effect of myopia on retinal nerve fibre layer (RNFL) thickness measurement by using spectral domain optical coherence tomography (Cirrus HD OCT) and scanning laser polarimetry with enhanced corneal compensator (GDx ECC). METHODS One hundred and forty-nine eyes of 149 myopic subjects were recruited and subdivided into three groups according to their refractive er...

PURPOSE To assess the prevalence of glaucoma in patients with high myopia defined as myopic refractive error of >-8 diopters or axial length ≥26.5 mm. METHODS The hospital-based observational study included 172 patients (336 eyes) with a mean age of 61.9±12.3 years and mean axial length of 30.1±2.3 mm (range: 24.7-39.1mm). Glaucomatous-type optic discs were defined by glaucomatous optic disc ...

tion of retinal fibers leads to myopia or myopia leads to myelination of retinal fibers. Alternatively, myopia and retinal myelination may be associated with other factors. Schmidt et al proposed that myelinated fibers could blur retinal images and induce visual deprivation. Such deprivation at a critical stage of ocular development could lead to axial elongation, akin to structural changes see...

PURPOSE To investigate the effect of overnight orthokeratology (OK) contact lens wear on axial length growth in East Asian children with progressive myopia. DESIGN A prospective, randomized, contralateral-eye crossover study conducted over a 1-year period. PARTICIPANTS We enrolled 26 myopic children (age range, 10.8-17.0 years) of East Asian ethnicity. METHODS Subjects were fitted with ov...

We studied the potential of myopic corneal refractive laser surgery to induce myopia (axial elongation) and potential interactions between aberrations (generally resulting from the procedure) and myopia development in chicks (Gallus domesticus). Ten white Leghorn chicks were monolaterally treated one day post-hatching with photorefractive keratectomy (PRK), with a nominal dioptric change of -9....