Evidence of several types has accumulated that cytochrome P-450 has a thiolate anion as one of the axial ligands to heme (the fifth ligand). On the other hand, there is as yet no general agreement on the nature of the axial ligand trans to thiolate (the sixth ligand), although nitrogen and oxygen have been proposed. To resolve the controversy, the ligand exchange reactions of cytochrome P-450 w...

Near-infrared photoimmunotherapy (NIR-PIT) is a novel phototherapy for the treatment of cancer that uses NIR light and conjugates antibody-IR700, silicon phthalocyanine photosensitizer. A key feature NIR-PIT light-induced axial ligand cleavage IR700, which finally causes cytotoxicity. Here, we focused on protonation IR700 anion radical during photochemical process. The Gibbs energy in reaction ...

The solvated title compound, [Fe(C44H28N4)(C4H6N2)(C7H7NO)]·CH2Cl2, is a porphyrin complex containing an octahedrally coordinated Fe(II) atom with 1-methylimidazole [Fe-N = 2.0651 (17) Å] and o-nitro-sotoluene ligands at the axial positions. The o-nitro-sotoluene ligand is N-bound to iron(II) [Fe-N = 1.8406 (18)Å and Fe-N-O = 122.54 (14)°]. The axial N-Fe-N linkage is almost linear, with a bond...

The crystal structure of the title triangulo-triruthenium compound, [Ru(3)(C(21)H(21)AsS(3))(CO)(11)], confirms that during the synthesis one equatorial carbonyl ligand is substituted by a monodentate arsine ligand, leaving one equatorial and two axial carbonyl substituents on an Ru atom. The other two Ru atoms each carry two equatorial and two axial carbonyl ligands. The three arsine-substitut...

The essential but also toxic gaseous signaling molecule nitric oxide is scavenged by the reduced vitamin B12 complex cob(II)alamin. The resulting complex, nitroxylcobalamin (NO--Cbl(III)), is rapidly oxidized to nitrocobalamin (NO2Cbl) in the presence of oxygen; however it is unlikely that nitrocobalamin is itself stable in biological systems. Kinetic studies on the reaction between NO2Cbl and ...

In the title compound, [Re(CF(3)COO)(CH(3)CN)(2)(CO)(3)], the Re atom has a distorted octa-hedral configuration. The two acetonitrile mol-ecules and two of the three carbonyl groups occupy the equatorial plane of the complex, with the third carbonyl ligand and the trifluoroacetato ligand in the axial positions. The three carbonyl ligands are arranged in a fac configuration around the Re atom. T...

Organocobalt complexes containing axial haloalkyl groups afford metallacycles of different size by N or O alkylation of the macrocyclic equatorial ligands. The reaction mechanism involves the intramolecular nucleophilic attack of a negatively charged atom of the equatorial ligand on the axial 2 XCH haloalkyl group with simultaneous detachment of a halide ion, X. In imino/oxime and amino/oxime d...