BACKGROUND Dysfunction of cerebral autoregulation might contribute to neurological morbidity after cardiac surgery. In this study, our aim was to assess the preservation of cerebral autoregulation after cardiac surgery involving cardiopulmonary bypass (CPB). METHODS Dynamic and static components of cerebral autoregulation were evaluated in 12 patients undergoing coronary artery bypass graft s...

OBJECTIVE To review methods of quantifying human cerebral autoregulation in health and disease. DATA SOURCES Articles and published abstracts on methods to quantify cerebral autoregulation in health and disease. SUMMARY OF REVIEW Cerebral autoregulation is defined as the relationship between cerebral blood flow and cerebral perfusion pressure. Complex neurohumoral processes are involved in ...

BACKGROUND AND PURPOSE To study cerebrovascular autoregulation and its impact on clinical course in patients with impending malignant middle cerebral artery infarction, we used invasive multimodal neuromonitoring, including measurement of cerebral perfusion pressure, tissue oxygen pressure, and microdialysis. METHODS Fifteen patients with a stroke that involved >50% of the middle cerebral art...

Cerebral autoregulation refers to regulation mechanisms that aim to maintain cerebral blood flow approximately constant. It is often assessed by autoregulation index (ARI), which uses arterial blood pressure and cerebral blood flow velocity time series to produce a ten-scale index of autoregulation performance (0 denoting the absence of and 9 the strongest autoregulation). Unfortunately, data a...

We have studied the effects of labetalol on cerebral blood flow (CBF) and cerebral oxygen metabolism (CMRO2) in eight healthy volunteers. CBF was measured by single photon emission computerized tomography before and during infusion of labetalol. CMRO2 was calculated as CBF x cerebral arteriovenous oxygen content difference (CaO2-CvO2). CBF autoregulation was tested during infusion of labetalol ...

response to normal pregnancy: a longitudinal study. postpartum) to investigate the effect of normal pregnancy on cerebral autoregulation and pressor response. Blood flow velocities in the right internal carotid artery, end-tidal CO 2, and mean arterial pressure (MAP) were simultaneously and continuously recorded in 16 healthy pregnant women during standardized hyperventilation and handgrip. Blo...

A study has been made into the effects of blood pressure on the spinal cord blood flow. Under conditions of normoxia and normocarbia a well-functioning autoregulation was present between 150-60 mmHg. Below 60 mmHg the flow decreased with reductions in pressure. In individual dogs, autoregulation was sometimes present to 40 mmHg. Under conditions of hypoxia or hypercarbia, autoregulation was abs...

Letter by Shang Regarding Article, “Relative Contributions of Sympathetic, Cholinergic, and Myogenic Mechanisms to Cerebral Autoregulation” To the Editor: The recent publication by Hamner and Tan, titled Relative Contributions of Sympathetic, Cholinergic, and Myogenic Mechanisms to Cerebral Autoregulation, was of great interest to our group. They analyzed the relationship between specific physi...

Letter by Shang Regarding Article, “Relative Contributions of Sympathetic, Cholinergic, and Myogenic Mechanisms to Cerebral Autoregulation” To the Editor: The recent publication by Hamner and Tan, titled Relative Contributions of Sympathetic, Cholinergic, and Myogenic Mechanisms to Cerebral Autoregulation, was of great interest to our group. They analyzed the relationship between specific physi...

Letter by Shang Regarding Article, “Relative Contributions of Sympathetic, Cholinergic, and Myogenic Mechanisms to Cerebral Autoregulation” To the Editor: The recent publication by Hamner and Tan, titled Relative Contributions of Sympathetic, Cholinergic, and Myogenic Mechanisms to Cerebral Autoregulation, was of great interest to our group. They analyzed the relationship between specific physi...