Autoimmune liver disease management goals are primarily slowing disease progression and symptomatic treatment. There are few options for curative medical management other than transplant for a spectrum of autoimmune liver disease that encompasses autoimmune hepatitis, primary biliary cirrhosis, primary sclerosing cholangitis as well as their overlap syndromes. These diseases are managed primari...

REFERENCES 1. Heurgué A, Vitry F, Diebold MD, et al. Overlap syndrome of primary biliary cirrhosis and autoimmune hepatitis: a retrospective study of 115 cases of autoimmune liver disease. Gastroenterol Clin Biol 2007; 31:17-25. 2. Rust C, Beuers U. Overlap syndromes among autoimmune liver diseases. World J Gastroenterol 2008; 14:3368-73. 3. Ebert EC. Gastrointestinal and hepatic manifestations...

We report the case of a 54-year-old woman with progressive systemic sclerosis who presented erythematous papules diagnosed in biopsy as lichen planus bullous (LPB). Systemic sclerosis (SSc) is an autoimmune connective tissue disease characterized by specific antibodies, vascular abnormalities with progressive damage of blood vessels and diffuse fibrosis leading to their failure. Sys-temic scler...

Autoimmune diseases arise from an abnormal immune response of the body against self-proteins leadingto tissue and organ damage. The excessive production of harmful autoantibodies (AAB) is a hallmarkof autoimmune diseases including Rheumatoid Arthritis (RA), Systemic Lupus Erythematodes (SLE),Systemic Sclerosis (SSc) and Sjögren’s Disease (SjS). Early diagnosis of autoimmune diseases...

Patients with autoimmune diseases are at an increased risk of cancer due to underlying dysregulation of the immune system or treatment. Data on cancer incidence, mortality and survival after autoimmune diseases would provide further information on the clinical implications. We systematically analysed data on lung cancer in patients diagnosed with 33 different autoimmune diseases. Standardised i...

BACKGROUND We conducted a study in order to determine the usefulness and diagnostic value of International Autoimmune Hepatitis Group (IAHG) score in non-autoimmune hepatitis (AIH) hepatic disorders as well as in AIH/overlap syndromes and in cases with coexistence of AIH and other liver diseases. METHODS We applied the IAHG score in 423 patients with liver diseases excluding patients with AIH...

Сhronic autoimmune hepatitis is an urgent problem of modern medicine due to the widespread prevalence among all diseases (more than 25%) and difficulty its diagnosis lack reliable serological tests for detection. The purpose this work was study possibility method monochrome analysis nanoparticles in noninvasive detection AIG develop algorithm rapid chronic by saliva. goal solved performing a nu...

Retroviruses have been implicated in the pathogenesis of several human autoimmune conditions including Sjögren's syndrome, primary biliary cirrhosis, immune mediated diabetes, and multiple sclerosis. The human intracisternal A type particle derived from Sjögren's syndrome patients' salivary glands was the first retrovirus to be isolated from a human autoimmune disorder but the agent has yet to ...

Autoimmune diseases are chronic inflammatory disorders caused by a loss of self-tolerance, which is characterized by the appearance of autoantibodies and/or autoreactive lymphocytes and the impaired suppressive function of regulatory T cells. The pathogenesis of autoimmune diseases is extremely complex and remains largely unknown. Recent advances indicate that environmental factors trigger auto...

The portal tract mononuclear cell infiltrate has been characterised in 28 liver biopsy samples showing features of chronic aggressive hepatitis from 12 patients with autoimmune chronic active hepatitis, 12 with primary sclerosing cholangitis, and four with other chronic liver diseases (two with alpha 1-antitrypsin deficiency, one with Wilson's disease, and one with chronic hepatitis B infection...