Introduction Large, segmental, osseous defects remain a major clinical problem. Common approaches to healing such defects include the use of autograft bone and the application of recombinant, human bone morphogenetic protein-2 (BMP-2) in the form of InfuseTM. Neither, however, is ideal. Supplies of autograft are limited and its harvest can be associated with considerable morbidity. BMP-2 is ext...

AIM The purpose of this study is to determine the outcome and complications of pregnancy in women with pulmonary autograft valve replacement for aortic valve disease. METHODS AND RESULTS The records of all women who had undergone pulmonary autograft valve replacement at the National Heart Hospital (now Royal Brompton Hospital) since 1968 were reviewed. From 1968 to 1993, 27 hospital survivors...

OBJECTIVE We performed a review of a consecutive series of 487 patients undergoing the Ross operation to identify surgical techniques and clinical parameters that affect outcome. METHODS We performed a prospective review of consecutive patients from August 1986 through June 2002 and follow-up through August 2004. Patient age was 2 days to 62 years (median, 24 years), and 197 patients were les...

OBJECTIVE To calculate clinical guidelines for the optimal location and size of a rotational autokeratoplasty. METHODS The ideal graft size and trephine decentration for a rotational autograft were calculated based on scar location using geometric models. Mathematical variables were set to maximize postoperative visual acuity and for generalization of the geometric model. This model was used ...

BACKGROUND After pulmonary autograft replacement of the aortic valve and root, the pulmonary artery (PA) wall is subjected to higher pressures. Concern exists that this may lead to structural and functional changes in the implanted autograft and subsequent aortic root dilatation and neoaortic regurgitation. We therefore assessed root dimensions and neoaortic regurgitation, morphological structu...

objective: as effectiveness of the autologous graft in the repair of long nerve defects is very limited an effective substitute is needed. this study was conducted to determine the poled polyvinylidene fluoride (pvdf) tube as an alternative to nerve autograft. materials and methods: the left sciatic nerve was transected in 45 male wistar rats. the animals were then divided randomly into three g...

In pediatric patients, the further growth potential is a major advantage in using the pulmonary autograft (Ross procedure). The authors describe a modified annuloplasty technique that appears to prevent the development of undesirable aortic regurgitation associated with root enlargement while not affecting overall tissue growth in the autograft.

Aim: To compare the recurrence rate of pterygium after excision with free conjunctival autograft versus amniotic membrane graft. Methods: The present study was a comparative, randomised prospective study. One hundred patients who presented with primary pterygium during the study period were randomly assigned to one of the two groupsone group (comprising of 50 patients) underwent pterygium excis...

OBJECTIVE To evaluate the safety, efficacy, and recurrence of pterygium following 90 degrees versus zero degrees and 180 degrees rotation autograft for treating primary pterygium. METHODS We included in this observational, prospective, and comparative study, 74 patients (47 males, 27 females) with advanced primary pterygium, with a mean age of 47.5 years (range 19-79 years). This study was co...

AIMS We analysed the outcome of young adults with congenital aortic valve disease who underwent allograft or autograft aortic valve or root replacement in our institution and evaluated whether there is a preference for either valve substitute. METHODS AND RESULTS Between 1987 and 2007, 169 consecutive patients with congenital aortic valve disease aged 16-55, participating in our ongoing prosp...