In asthmatic subjects there is a pronounced diurnal variation in bronchial responsiveness. If this phenomenon is due to variation in factors that control drug delivery, then it should be paralleled by a similar variation in competitive antagonist blockade. In order to study this possibility, we performed the methacholine challenge test and after 45 minutes, administered atropine by inhalat...

BackgroundLittle is known about changes in astigmatism during atropine treatment. We aimed to explore the effects of 0.01% eye drops on both spherical and cylindrical refractive errors myopic children.MethodsChildren aged 6–14 years with myopia ≥ −6.00 D < −0.50 D, total > −2.00 at least one were enrolled. Subjects randomised either receive once nightly single-vision lenses or simply wear follo...

Objective: To determine the safety and cardiac chronotropic responsiveness to early atropine dobutamine stress echocardiography (DSE) in the elderly. Design: Retrospective study of 258 patients > 70 years who underwent early atropine DSE and 290 patients> 70 years who underwent conventional DSE. In the early atropine protocol, atropine was started at 20 mg/kg/min of dobutamine if heart rate was...

OBJECTIVE To determine the safety and cardiac chronotropic responsiveness to early atropine dobutamine stress echocardiography (DSE) in the elderly. DESIGN Retrospective study of 258 patients >or= 70 years who underwent early atropine DSE and 290 patients >or= 70 years who underwent conventional DSE. In the early atropine protocol, atropine was started at 20 microg/kg/min of dobutamine if hea...

OBJECTIVES Our objectives were to describe the prevalence of arrhythmia and conduction abnormalities before critical care intubation and to test the hypothesis that atropine had no effect on their prevalence during intubation. DESIGN Prospective, observational study. SETTING PICU and pediatric/neonatal intensive care transport. SUBJECTS All children of age less than 8 years intubated Sept...

Transmural electrical stimulation of segments of lingual and cerebral (basilar, middle and posterior cerebral) and also other cranial arteries of the cat results after a long latency in a dilator response. The response may be resolved into two components--an initial transient atropine-sensitive component and a slower more ponderous one that is atropine-resistant. The variability in pattern of d...

Atropine is a non-selective muscarinic receptor antagonist. In overdoses, atropine is poisonous. It is sometimes added to potentially addictive drugs, particularly anti-diarrhoea opioid drugs such as diphenoxylate or difenoxin. The aim of this study was to investigate spatial memory and motor changes associated with varying doses (5 and 10 mg/kg body weight) ingestion of atropine, as well as it...

Alcoholic and water extracts of many medicinal plants are commonly used in German folk medicine and other countries as antispasmodics. However, so far no data on dose relationships or comparisons of the antispasmodic effects with reference substances have been available for most of these plant extracts. Using acetylcholine as the stimulating agent, the antispasmodic effect of preparations ...

OBJECTIVE Exercise stress test (EST) is one of the main diagnostic and prognostic tests for ischemic heart disease. However, its usefulness depends on achieving target heart rate, then chronotropic incompetence and poor exercise capacity limits its utility. We evaluated the usefulness of atropine administration during the EST to decrease the number of tests with inconclusive results in these pa...

Purpose: To report successful graft reattachment using atropine after Descemet’s membrane stripping automated endothelial keratoplasty (DSAEK) in iris deformity.Case summary: A 76-year-old male was referred for decreased visual acuity due to bullous keratopathy his right eye. He had previously undergone several eye surgeries, including vitrectomy and intraocular lens fixation, because of retina...