نتایج جستجو برای: atovaquone

تعداد نتایج: 456  

Journal: :Antimicrobial agents and chemotherapy 2002
S Gupta M M Thapar W H Wernsdorfer A Björkman

The interactions of artemisinin with atovaquone, quinine, and mefloquine were investigated in three Plasmodium falciparum strains (strains F-32, FCR-3, and K-1) by an in vitro culture assay. The parasites were cultured for 48 h in the presence of different concentrations and proportions of two drugs at a time in a checkerboard design. The response parameters were determined, and the sums of the...

2014
Mateusz M. Plucinski Curtis S. Huber Sheila Akinyi Willard Dalton Mary Eschete Katharine Grady Luciana Silva-Flannery Blaine A. Mathison Venkatachalam Udhayakumar Paul M. Arguin John W. Barnwell

BACKGROUND Atovaquone-proguanil (AP) is the most commonly used treatment for uncomplicated Plasmodium falciparum malaria in the United States. Apparent AP treatment failures were reported 7 months apart in 2 American travelers who stayed in the same compound for foreign workers in Rivers State, Nigeria. METHODS We analyzed pretreatment (day 0) and day of failure samples from both travelers fo...

2017
Ana Carolina Rennó Sodero Bárbara Abrahim-Vieira Pedro Henrique Monteiro Torres Pedro Geraldo Pascutti Célia RS Garcia Vitor Francisco Ferreira David Rodrigues da Rocha Sabrina Baptista Ferreira Floriano Paes Silva

BACKGROUND Malaria persists as a major public health problem. Atovaquone is a drug that inhibits the respiratory chain of Plasmodium falciparum, but with serious limitations like known resistance, low bioavailability and high plasma protein binding. OBJECTIVES The aim of this work was to perform molecular modelling studies of 2-hydroxy-1,4-naphthoquinones analogues of atovaquone on the Qo sit...

Journal: :The Journal of veterinary medical science 2016
Aiko Iguchi Takehisa Soma Hiroshi Suzuki Xuenan Xuan

In 73 gDNA samples from Babesia gibsoni-infected dogs, the M121I variant population was measured by using allele-specific real-time PCR. Although the mechanism of atovaquone against B. gibsoni has not been clearly identified, it is reported that the mitochondria cytochrome b gene of the atovaquone-resistant B. gibsoni had a single-nucleotide substitution at nt363 (G to T), which resulted in the...

Journal: :Antimicrobial Agents and Chemotherapy 1997

Journal: :Biomedical microdevices 2011
Javier Calvo José Luis Lavandera Maite Agüeros Juan M Irache

The aim was to study the ability of bioadhesive cyclodextrin-poly(anhydride) nanoparticles as carriers for the oral delivery of atovaquone (ATO). In order to increase the loading capacity of ATO by poly(anhydride) nanoparticles, the following oligosaccharides were assayed: 2-hydroxypropyl-β-cyclodextrin (HPCD), 2,6-di-O-methyl-β-cyclodextrin (DCMD), randomly methylated-β-cyclodextrin (RMCD) and...

2016
Kyle Petersen David P Regis

BACKGROUND Recreational diving occurs annually in areas of the world where malaria is endemic. The safety and efficacy of antimalarials for travelers in a hyperbaric environment is unknown. Of particular concern would be medications with adverse effects that could either mimic diving related illnesses such as barotrauma, decompression sickness (DCS) and gas toxicities, or increase the risk for ...

Journal: :Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 2010
Gary P Wormser Aakanksha Prasad Ellen Neuhaus Samit Joshi John Nowakowski John Nelson Abraham Mittleman Maria Aguero-Rosenfeld Jeffrey Topal Peter J Krause

BACKGROUND Babesiosis is an emerging tickborne malaria-like infection principally caused by Babesia microti. This infection typically resolves either spontaneously or after administration of a 7-10-day course of azithromycin plus atovaquone or clindamycin plus quinine. Although certain highly immunocompromised patients may respond suboptimally to these drug regimens, unlike the situation with m...

Journal: :Journal of travel medicine 2006
Beatriz C Jiménez Miriam Navarro Helena Huerga Eva López-Román Alfonso Mendoza Rogelio López-Vélez

There is limited data regarding the efficacy of prophylaxis with atovaquone/proguanil (A/P) against non-falciparum malaria in travelers. Two cases, one Plasmodium vivax infection and another Plasmodium ovale infection, in travelers despite A/P prophylaxis are presented.

Journal: :Antimicrobial agents and chemotherapy 2010
Heather J Painter Joanne M Morrisey Akhil B Vaidya

Although mitochondrial electron transport is a validated target of the antimalarial drug atovaquone, the molecular details underlying parasite demise are unclear. We have shown that a critical function of mitochondrial electron transport in blood-stage Plasmodium falciparum is to support pyrimidine biosynthesis. Here, we explore the effects of atovaquone, alone and in combination with proguanil...

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