We have characterized the covalent poly(ADP-ribosyl)ation of p53 using an in vitro reconstituted system. We used recombinant wild type p53, recombinant poly(ADP-ribose) polymerase-1 (PARP-1) (EC ), and betaNAD(+). Our results show that the covalent poly(ADP-ribosyl)ation of p53 is a time-dependent protein-poly(ADP-ribosyl)ation reaction and that the addition of this tumor suppressor protein to ...

This paper provides an analytically tractable general-equilibrium model of money demand with micro-foundations. The model is based on the incomplete-market model of Bewley (1980) where money serves as a store of value and provides liquidity to smooth consumption. The model is applied to study the e¤ects of monetary policies. It is shown that heterogeneous liquidity demand can lead to sluggish m...

We use results from the literature on the determinants of price-cost margins to derive an equation relating labor's share of national income to the in ‡ation rate (as well as to the output gap, the unemployment rate and the capital stock per worker). The equation is tested with a panel of 15 OECD countries. We obtain a robust positive relationship between in ‡ation and the labor share. Our resu...

We investigate, in a model-independent way, the conditions required to obtain a satisfactory model of extended in ation in which in ation is brought to an end by a rst-order phase transition. The constraints are that the correct present strength of the gravitational coupling is obtained, that the present theory of gravity is satisfactorily close to general relativity, that the perturbation spec...

The paper examines the e¤ect of in‡ation on growth in transition countries. It presents panel data evidence for 13 transition countries over the 1990-2003 period; it uses a …xed e¤ects, full-information maximum likelihood, panel approach to account for possible bias from correlations among the unobserved e¤ects and the observed country heterogeniety. The results …nd a strong, robust, negative e...

This paper proposes a di¤erent empirical approach to estimate the UIP by analyzing a large number of cross-country bilateral exchange rates using cross-section analysis. Di¤erent from conventional time-series UIP, cross-sectional UIP is examined with single equation estimation and panel regression model estimation. The exchange rates analyzed here include a broad spectrum of countries: develope...

4.1 Molecular biology methods 28 4.1.1 Construction of expression plasmids 28 4.2 Cell biology methods 29 4.2.1 Cell culture and transfection 29 4.2.2 ImmunoFISH 30 4.2.3 Microscopy, image analysis and statistical evaluation 31 4.3 Biochemical methods 32 4.3.1 In vivo protein interaction assays 32 4.3.2 In vitro protein interaction assays 33 4.3.3 Western blot analysis 34 4.3.4 In vitro poly(AD...

Serge Autexier1 and Dieter Hutter2 and Till Mossakowski3 and Axel S hairer2 1 FR 6.2 Informatik, Saarland University, P.O. Box 15 11 50, D 66041 Saarbr u ken, Autexier ags.uni-sb.de 2 DKFI GmbH, Stuhlsatzenhausweg 3, D 66123 Saarbr u ken, hutter dfki.de 3 FB 3, University of Bremen, P.O. Box 330 440, D 28334 Bremen, till tzi.de 1 Overview The use of formal methods is propagated to in rease th...

Damour and Mukhanov have recently devised circumstances in which in ation may continue during the oscillatory phase which ensues once the in aton eld reaches the minimum of its potential. We con rm the existence of this phenomenon by numerical integration. In such circumstances the quanti cation of the amount of in ation requires particular care. We use a de nition based on the decrease of the ...

Conventional wisdom is that in‡ation makes people spend their money faster, trying to get rid of it like a “hot potato.” Intuitively, this is one channel through which in‡ation increases velocity in theory (as in the data). Search-based monetary models seem ideal for studying this phenomenon. However, in the standard model, in‡ation acts like a tax, lowering the surplus associated with monetary...