OBJECTIVE To evaluate the performance of traditional cardiovascular (CV) risk factors in identifying a higher than expected coronary atherosclerotic burden. METHODS We assessed 2069 patients undergoing coronary CT angiography, with assessment of calcium score (CS), for suspected coronary artery disease. A higher than expected atherosclerotic burden was defined as CS >75th percentile (CS >P75)...

This review assesses the current status of knowledge concerning the relationship of risk factors to atherosclerotic lesions. Risk factors for atherosclerotic lesions per se need not necessarily be identical to those related to clinically overt coronary heart disease (CHD). This review is based on 1) autopsy studies where information risk factors was gathered in a retrospective fashion; and 2) a...

Objective. To examine the frequency and patterns of association of cardiovascular risk factors with atherosclerosis in five different arterial territories at post-mortem in Mexico City. Methods. We obtained five arterial territories arteries (circle of Willis, coronary, carotid, renal, and aorta) of 185 men and women 0 to 90 years of age who underwent autopsy at the Medical Forensic Service of ...

Background Infertility is the inability to conceive children after one year of unprotected intercourse. The estimated prevalence of infertility in Canada is 11.5-15.7%. Fertility problems affect approximately one in seven couples in the United Kingdom (UK). Infertility occurs in conditions in which the pregnancies end with recurrent miscarriages (ASR) or birth of a child with multiple congenita...

OBJECTIVE Infants of diabetic mothers (IDM) are considered as a risk group for atherosclerosis. Increased aortic intima-media thickness has been reported in IDM. The purpose of this study was to assess carotid artery intima-media thickness (CA-IMT), left ventricular mass index (LVMI) and atherosclerotic risk factors in IDM. METHODS Thirty IDM and 25 healthy controls were included in the study...

Background & Objective: Sex differences in cerebral atherosclerosis and subsequent stroke have not been thoroughly investigated and conflicting data exist. The aim of this study was to investigate sex differences in the risk factors and distribution of large artery atherosclerotic stroke in a Korean population. Methods: We included consecutive acute ischemic stroke patients with symptomatic ext...

Background: MLKL, one of the main downstream components of the necroptosis or programmed necrosis has recently been demonstrated in advanced atherosclerotic lesions. However, its precise role in the atherosclerosis pathogenesis still requires more elucidation. Our study was set to delineate both the changes in peripheral MLKL gene expression and its influence on disease severity in atherosclero...

Traditional Risk Factors and Vascular Risk Most data derived from large populations pertaining to risk factors for noncoronary AVD are found in studies primarily focusing on coronary heart disease (CHD), such as the Framingham Heart Study,1 the Atherosclerosis Risk in Communities Study (ARIC),2 the Honolulu Heart Study,3 and the Strong Heart Study.4 With rare exception, the evidence from these ...