Atherosclerosis is an inflammatory, proliferative, thrombotic arterial disease initiated by risk factor injury to the endothelium. Although obstructive plaques develop locally, the disease is always diffuse if examined by intravascular ultrasound or histology. Assessing and treating the initiating risk factors and the resulting obstructive disease has been the traditional approach to managing a...

INTRODUCTION Chronic inflammations including infectious disorders such as HIV infection are now considered as risk factors for atherosclerosis. In this study, conducted for the first time on human subjects, human T-lymphotropic virus type 1 (HTLV-1) infection was examined as a potential risk factor for atherosclerosis. MATERIALS AND METHODS This is a matched-pair cross-sectional study on 58 H...

BACKGROUND AND PURPOSE The association between abdominal obesity and atherosclerosis is believed to be due to excess visceral adipose tissue (VAT), which is associated with traditional risk factors. We hypothesized that VAT is an independent risk factor for atherosclerosis. METHODS Healthy men and women (N=794) matched for ethnicity (aboriginal, Chinese, European, and South Asian) and body ma...

According to postmortem studies, coronary atherosclerosis can be substantial and reach a high prevalence of advanced lesions, including atheroma and fibroatheroma in young adults.1,2 Risk factors associated with coronary atherosclerosis such as dyslipidemia, smoking, diabetes mellitus, and hypertension have been identified. The development of atherosclerosis seems to be related to the magnitude...

Background and Purpose—Parity appears to be associated with carotid atherosclerosis in women aged 45 years and older. Studying this association among younger women and men may provide insight into whether this association relates predominantly to childbearing or child-rearing. Methods—The association between parity and carotid atherosclerosis (intima-media thickness and presence of plaques) was...

Disorders likely ‘inflammatory’ in nature are known to be linked accelerated atherosclerotic processes that increase the chances of cardiovascular disease. Systemic lupus erythematosus (SLE) is a well-known autoimmune disease for its ability affect any organ and cause morbidity. One such major morbidity mortality SLE premature coronary heart Inflammation considered main pathogenesis atheroscler...

BACKGROUND AND PURPOSE Parity appears to be associated with carotid atherosclerosis in women aged 45 years and older. Studying this association among younger women and men may provide insight into whether this association relates predominantly to childbearing or child-rearing. METHODS The association between parity and carotid atherosclerosis (intima-media thickness and presence of plaques) w...

BACKGROUND The risk factors for intracranial atherosclerosis are unclear but may differ from those for other stroke subtypes. Here, we investigated whether metabolic syndrome, an emerging risk factor for cardiovascular disease, is associated with intracranial atherosclerotic stroke. METHODS Using the Adults Treatment Panel III criteria, we evaluated the components of metabolic syndrome in 439...

While coronary heart disease is the leading cause of death in women in the United States, research in the area is lacking, especially concerning psychosocial risk factors. The purpose of this experiment was to study the effect of a known psychosocial risk factor in female monkeys, social status, and the effect of alteration of social status on coronary artery atherosclerosis. In previous experi...