Conjugates of mitomycin C (MMC) with estradiol bezoate and estradiol via glutaric acid (EB-glu-MMC and E-glu-MMC, respectively) were examined for their antitumor activities against P388 leukemia and sarcoma 180. EB-glu-MMC and E-glu-MMC were suspended in 10% (v/v) propylene glycol in saline and administered intraperitoneally to mice bearing P388 leukemia intraperitoneally or to mice bearing sar...

Influx ofd-aspartate (d-Asp),l-glutamate (l-Glu), and serine (Ser) across the brush-border membrane of the intact mucosa from rabbit ileum has been examined. l-Glu influx is chloride independent and completely sodium dependent.d-Asp andl-Glu share a transport system with a maximum transport rate of 1 μmol ⋅ cm-2 ⋅ h-1and an apparent affinity constant ( K ½) of ∼0.3 mM. The function of this tran...

A toxic organic substance CCl4 is a well known model compound for studying detoxification function of the liver and developing oxidative stress. The goal study was to estimate effect L-glutamic acid (L-Glu) N-acetylcysteine (NAC) administration on rat blood parameters upon effects CCl4. Experimental male Wistar rats were injected intraperitoneally with CCl4, CCl4/L‑Glu group additionally L-Glu ...

Three types of apolipoprotein A-II (apoA-II) proteins (A, B and C) were predicted from the nucleotide sequence of apoA-II cDNA. Substitution of amino acid residues was noted at four positions (type A: Pro-5, Asp-20, Met-26, Ala-38; B: Pro-5, Glu-20, Val-26, Val-38; C: Gln-5, Glu-20, Val-26, Ala-38). Each type was identifiable by digestion of amplified apoA-II DNA by PCR, using restriction-fragm...

In wheat ( Triticum aestivum L), the synthesis of high molecular weight (HMW) glutenins (GS) is controlled by three heterologous genetic loci present on the long arms of group 1 wheat chromosomes. The loci Glu-A1, Glu-B1, and Glu-D1 and their allelic variants play important roles in the functional properties of wheat flour. This study focused on understanding the functionality of these protein ...

Monoclonal antibody NYS4 recognizes a single 140 kDa antigen on the surface of Plasmodium yoelii sporozoites, an antigen which is distinct from the extensively characterized circumsporozoite (CS) protein. To more thoroughly characterize this additional surface component, a genomic expression library was screened with NYS4 and an immunoreactive clone (M4) was obtained which expressed part of the...

BACKGROUND In a previous pilot study comparing insulin glulisine (GLU) with insulin aspart (ASP) administered by continuous subcutaneous insulin infusion (CSII), GLU-treated patients did show a trend toward fewer catheter occlusions compared with ASP-treated patients. Here we performed a randomized open-label, three-way crossover, controlled multicenter study comparing GLU with ASP and insulin ...

The purposes of this study were: 1) to obtain a measure of exogenous carbohydrate (CHO(Exo)) oxidation and plasma glucose kinetics during 5 h of exercise; and 2) to compare CHO(Exo) following the ingestion of a glucose solution (Glu) or a glucose + fructose solution (2:1 ratio, Glu+Fru) during ultraendurance exercise. Eight well-trained subjects exercised three times for 5 h at 58% maximum O2 c...

Abstract 
 Moringa leaves (Moringa oleifera Lam) is one of the potential local feed ingredients broiler rations due to its nutrient contents such as carbohydrate (57,01%), crude protein (30,30%), fat (2,74%) well a source vitamin C, carotenoids and flavonoids. This study aimed determine effect using different levels Lam leaf meal (MOLM) in basal ration on plasma metabolites, including tota...

Agropyron cristatum (P genome) is a Triticeae species from the wheat tertiary gene pool which has economic importance as forage and also displays traits beneficial to wheat. Resistance leaf rust was previously mapped short arm of chromosome 1P (1PS) in A. by development compensating Robertsonian translocation involving 1PS long 1B (1BL). In this study, engineered using ph1b mutation induce 1BS/...