Abstract: The main difficulty in the overall process of optimal assembly plan generation is the great number of different ways to assemble a product (typically thousands of solutions). This problem confines the application of most existing automated planning methods to products composed of only a limited number of components. The presented method of assembly plan generation belongs to the appro...

Bacterial natural products are a diverse and valuable group of small molecules, and genome sequencing indicates that the vast majority remain undiscovered. The prediction of natural product structures from biosynthetic assembly lines can facilitate their discovery, but highly automated, accurate, and integrated systems are required to mine the broad spectrum of sequenced bacterial genomes. Here...

Abstract We construct secondary cup and cap products on coarse (co-)homology theories from given cross slant products. They are defined for spaces relative to weak generalized controlled deformation retracts. On ordinary cohomology, our product agrees with a by Roe. For coarsifications of topological theories, correspond the primary Higson dominated coronas via transgression maps. And in case $...

background; work-related musculoskeletal disorders (wmsds) may involve all parts of the body, and have been a worldwide problem. employed women are two to five times more likely to report such problems, and assembly lines suspected to induce more wmsds because of high rate of repetitive motions. methods;the aim of this study to determine the prevalence of wmsds in women workers of an automobile...

Amyloid-β (Aβ) self-assembly into cross-β amyloidfibrils is implicated in a causative role in Alzheimer’s disease pathology.Uncertainties persist regarding the mechanisms of amyloid self assembly and the role of metastable prefibrillar aggregates. Aβ fibrilsfeature a sheet-turn-sheet motif in the constituent β-strands; as such, turn nucleation has been proposed as a rate-limiting step in the se...