Although proteins consist exclusively of L-amino acids, we have reported that aspartyl (Asp) 58 and Asp 151 residues of αA-crystallin of eye lenses from elderly cataract donors are highly inverted and isomerized to D-β, D-α and L-β-Asp residues through succinimide intermediates. Of these Asp isomers, large amounts of D-β- and L-β-isomers are present but the amount of D-α-isomer is not significa...

A polypeptide of Mr 4400 was isolated from soybean (Glycine max) seeds by extraction with 60% ethanol followed by ion-exchange and reverse-phase chromatography. The peptide contains an unusually high amount of aspartic acid residues (approximately 25%, and hence is designated as soybean aspartic acid-rich peptide). Its complete primary structure was determined by conventional methods to be the ...

2 Ser Asn Asn Asn 14 Leu Ile Leu Leu 22 Ser Ser Leu Leu 31 Val Asp Val Val 67 Thr Ala Thr Ala 116 Val Ile Ile Ile 183 Ala Ala Glu Glu 210 Ala Ser Ser Ser 233 Val Ala Ala Ala 262 Thr Ile Thr Thr 277 Gln Gln Arg Gln 294 Thr Val Val Val 296 Pro Ser Ser Ser 305 Ala Ser Ser Ser 314 Ile Val Val Val 317 Glu Lys Lys Lys 378 Ile Leu Leu Leu 415 Leu Val Val Val 417 Asp Gly Gly Gly 421 Val Ala Ala Ala 432...

The use of acetylsalicylic acid (ASP) is limited by its adverse effects, especially the effect on the gastric mucosa. To address this problem, we synthesized a derivative form of ASP, prepared by modification of ASP with nano-hydroxyapatite (a kind of inorganic particle containing Ca(2+)). The derivative was named Ca-ASP. Structural study showed that Ca-ASP was a kind of carboxylate containing ...

The aim of this study was to examine the effect of ACS14, a hydrogen sulfide (H(2)S)-releasing derivative of aspirin (Asp), on Asp-induced gastric injury. Gastric hemorrhagic lesions were induced by intragastric administration of Asp (200 mg/kg, suspended in 0.5% carboxymethyl cellulose solutions) in a volume of 1 ml/100 g body weight. ACS14 (1, 5 or 10 mg/kg) was given 30 min before the Asp ad...

Acylation Stimulating Protein (ASP) was recently purified to homogeneity from human plasma and shown to be identical to C3adesArg. ASP stimulates triglycerides synthesis in human skin fibroblasts and primary human adipocytes. In vitro differentiation of human preadipocytes to mature fat cells results in increased expression and accumulation of ASP in the medium. These differentiated human adipo...

This paper introduces an extension of Answer Set Programming (ASP) called Hybrid ASP which will allow the user to reason about dynamical systems that exhibit both discrete and continuous aspects. The unique feature of Hybrid ASP is that it allows the use of ASP type rules as controls for when to apply algorithms to advance the system to the next position. That is, if the prerequisites of a rule...

This paper describes an exploratory field study on the adoption of Application Service Provisioning (ASP) in Small and Medium-sized Enterprises (SMEs). Rooted in Merton’s Motivation-Ability model of innovation, and based on an integrated multi-theoretical framework, several factors are identified, which drive and enable ASP adoption. The results of the survey indicate that the primary drivers f...

The contents of GABA, glutamine (Glu) and asparagine (Asp) acids as well as activities of glutamatdecarboxylase (GDK; CF 4.1.1.15) and 4-aminobutirat: 2-oxoglutarataminotransferase (GABA-T: CF 2.6.1.19) in brain cortex, cerebellum, brainstem and hypothalamus under impact of testosterone propionate at a dose of 5 mg/100 g of alive weight of adult albino male rats in spring and autumn were studie...

BACKGROUND AND PURPOSE To assess the role of the endothelial nitric oxide synthase (eNOS) gene variants as risk factors for early atherosclerosis, we sought to investigate whether two polymorphisms located in the exon 7 (Glu298-->Asp) and in the promoter region (T-786-->C) of the eNOS gene were associated with functional changes in the endothelium and carotid intima-media thickness (IMT). MET...