The often time-consuming and challenging multi-step synthesis of ligands for metal-organic cages is a limiting factor the discovery application new cages. We report highly efficient copper-free one-pot Sonogashira-type coupling preparation symmetric diarylalkyne on both small large scale; bipyridine- benzimidazole-based self-assembly Co4L6 were synthesized in short reaction times high isolated ...

Arylation of heteroarene has been intensively studied over the past few years because aryl-substituted aromatic heterocycles are known to exhibit interesting biological activities and are also useful as electronic materials. Numerous methods have been reported to successfully construct this motif by transition-metal-catalyzed cross-coupling and most of them required expensive transition-metal c...

Transforming C(sp3)–H bonds efficiently and selectively into C(sp3)–C(sp3) or C(sp3)–X is a highly relevant task. The direct arylation of allylic provides an elegant method for the formation unconjugated aryl-substituted olefins. Although both ionic- radical-based transition metal catalysis has been applied to achieve this transformation, numerous challenges remain. requirement persistent radic...

Metal-catalyzed cross-coupling reactions have developed into a standard component of the synthetic chemist’s toolbox [1–4]. These reactions date to thework ofUllmann and Goldberg in the early 1900s on copper-promoted C–C and C–heteroatom bond formations. Copper remained the catalyst of choice for these reactions until the pioneeringwork ofHeck, Suzuki, Stille, Negishi, and others on palladium-c...

The Front Cover shows a public transportation map representing the synthetic trip from an aryl halide to heterocyclic diarylalkyne ligand. “multi-stop” route or conventional step-wise synthesis involves long reaction times and “stops” for isolation of intermediates. In contrast, reported “non-stop” via one-pot copper-free Sonogashira-type coupling is faster avoids formation Glaser products “acc...