To discover novel scaffolds as leads against dementia, a series of δ-aryl-1,3-dienesulfonyl fluorides with α-halo, α-aryl and α-alkynyl were assayed for ChE inhibitory activity, in which compound A...

A new biaryl monophosphine ligand (AlPhos, L1) allows for the room-temperature Pd-catalyzed fluorination of a variety of activated (hetero)aryl triflates. Furthermore, aryl triflates and bromides that are prone to give mixtures of regioisomeric aryl fluorides with Pd-catalysis can now be converted to the desired aryl fluorides with high regioselectivity. Analysis of the solid-state structures o...

Acetylcholinesterase purified from cobra (Naja naja) venom exhibits a serotonin-sensitive aryl acylamidase activity. Both acetylcholinesterase and aryl acylamidase activities co-eluted in column chromatographic procedures (Sephadex G-75 and Zinc-Sepharose), co-migrated on polyacrylamide gel electrophoresis, co-immunoprecipitated by anti-snake venom antibody and showed the same heat denaturation...

We describe the functionalization of α-amino C-H bonds with aryl halides using a combination of nickel and photoredox catalysis. This direct C-H, C-X coupling uses inexpensive and readily available starting materials to generate benzylic amines, an important class of bioactive molecules. Mechanistically, this method features the direct arylation of α-amino radicals mediated by a nickel catalyst...

We have successfully developed a novel cathodic cross-coupling reaction of aryl halides with arenes. Utilization of the cathodic single electron transfer (SET) mechanism for activation of aryl halides enables the cross-coupling reaction to proceed without the need for any transition metal catalysts or single electron donors in a mild condition. The SET from a cathode to an aryl halide initiates...

a series of new 2-arylimino-3-aryl-5-[5?-(3,4-dichlorophenyl)-2?-furylidene]-4-thiazolidinones (3a-l) have been synthesised by the condensation of 5-(3,4-dichlorophenyl)-2-furaldehyde 1 with 2-arylimino-3-aryl-5h-4-thiazolidinones 2 in glacial acetic acid. the physical and spectral data of the synthesised compounds are determined. the synthesised compounds have been screened for their in vitro ...

a simple and mild procedure for the conversion of anilines into aryl isocyanates is described using the 3-hydroxypropylammonium acetate (hpaa) ionic liquid as a novel and efficient media has been explored in the synthesis of aryl isocyanates from the reaction of substituted urea with sodium nitrite in a water immiscible solvent. this ionic liquid can be easily recovered and reused for many time...

an efficient method has been developed for the catalysis of condensation of 1,2-phenylenediamines and 2-aminothiophenoles with different aldehydes into their corresponding 2-aryl-1h-benzimidazoles and 2-aryl-1h-benzothiazoles under mild condition. in this method, trans-3,5-dihydroperoxy-3,5-dimethyl-1,2-dioxolane (dhpdmdo)/hoac/ki system was used as a novel and effective oxidant in water at roo...

Diaryliodonium salts are shown to undergo rapid, fluoride-promoted aryl exchange reactions at room temperature in acetonitrile. Aryl exchange is shown to be exquisitely sensitive to the concentration of fluoride ion in solution; fast exchange is observed as the fluoride concentration approaches a stoichiometric amount at 50 mM substrate concentration. The reaction is slowed, but not halted if b...