BACKGROUND Folate receptor β (FRβ) is involved in facilitating cellular uptake of folates and anti-folates (such as methotrexate (MTX)). In rheumatoid arthritis, FRβ is expressed on synovial macrophages and recently has been explored as a biomarker for imaging in arthritic rats using the folate-based positron emission tomography (PET) tracer [18F]fluoro-PEG-folate. The purpose of this study was...

This study aimed to identify how the elderly in Nigeria manage osteo-arthritic pain; their descriptions of and relationship between management strategies relief pain. Using structured interviews, data were collected from 236 people on quality pain experienced; modalities used effect such The results revealed that most respondents (79.7%) perceived as being excruciating; occurring all time (80.9...

Short term immobilisation (seven days) of an antigen induced arthritic knee joint of the mouse led to attachment of polymorphonuclear leucocytes to the cartilage surface and severe cartilage damage. The events at the patellar cartilage surface were studied by scanning electron microscopy and compared with the changes found in non-immobilised arthritic joints. At day 7 the immobilised arthritic ...

Rheumatoid arthritis is a chronic, inflammatory and autoimmune disorder. joint destruction which occurs due to increased expression of cytokines transcription factors. Cissus quadrangularis belongs the Vitaceae family. The plant shows anti-osteoporotic, anti-inflammatory anti-microbial properties. Soxhlet method was used for extraction using methanol as solvent. anti-arthritic activity methanol...

The aim of this study was to ascertain the anti-arthritic active fraction of Capparis spinosa L. (Capparidaceae) fruits and its chemical constituents. The adjuvant arthritic rat model was developed to evaluate the anti-arthritic effects of different fractions of ethanol extraction from C. spinosa L. The fraction eluted by ethanol-water (50:50, v/v) had the most significant anti-arthritic activi...

We examined the diurnal sleep-wake patterns in the adjuvant arthritic rat. In contrast to control rats, arthritic rats lacked a normal diurnal variation in sleep and wakefulness. Thus, arthritic rats exhibited no differences in the mean number or duration of bouts of sleep and episodes of wakefulness between light and dark hours. Arthritic rats also had a marked increase in the fragmentation of...