The work in this thesis was carried out in the context of the Artemisia project supported by PROGRESS/STW.

the formation of hemozoin (malaria pigment) has been proposed as an ideal drug target for antimalarial screening programs. in this study, we used an improved, cost-effective and high-throughput spectrophotometric assay to screen plant extracts for finding novel antimalarial plant sources. fifteen extracts with different polarity from three iranian artemisia species, a. ciniformis, a. biennis an...

The title compound, C(17)H(16)O(6), was isolated from the Chinese Tibetan medicinal plant Artemisia sphaerocephala Kraschen. The mol-ecular conformation is consolidated by two intra-molecular O-H⋯O hydrogen bonds. A further inter-molecular O-H⋯O hydrogen bond leads to chains along [010] in the crystal structure.

Two effective cytochrome P450 (CYP) inhibitors were isolated from tarragon, Artemisia dracunculus. Their structures were spectroscopically identified as 2E,4E-undeca-2,4-diene-8,10-diynoic acid isobutylamide (1) and 2E,4E-undeca-2,4-diene-8,10-diynoic acid piperidide (2). Both compounds had dose-dependent inhibitory effects on CYP3A4 activity with IC50 values of 10.0 ± 1.3 µM for compound 1 and...

A combination of solid-phase-extraction (SPE) and reversed-phase preparative high-performance liquid chromatography (prep-HPLC) of the methanolic extract of the aerial parts of Artemisia splendens (common name: “Asia Minor Wormwood”), an endemic Iranian species, afforded Zand E-melilotosides (1 and 2), Zand E-4-methoxy-melilotosides (3 and 4), and a new dimer, bis-ortho-Z-melilotoside (5, named...

Artemisia species, widespread in nature, are frequently utilized for the treatment of diseases such as malaria, hepatitis, cancer, inflammation, and infections by fungi, bacteria, and viruses. Furthermore, some Artemisia constituents were found to be potential insecticides and allelopathic chemicals. This genus is receiving growing attention presumably due to: (i) the diversified biology and ch...

Essential oil from aerial parts of Artemisia vulgaris L., was obtained by hydro-distillation to produce oil in the yield of 0.25% (w/w). The oil was analyzed by capillary gas chromatography, using mass spectrometric detection. The amount of the samples injected by nano scale included were 1.0 nL (diluted 1.0 μL of sample in 1000 ml of n-pentane, v/v). Twenty three bioactive and flavour molecule...

In this study Artemisia amygdalina a critically endangered medicinal plant endemic to Kashmir Himalayas was grown under in vitro conditions. ISSR markers were used to study the somaclonal variation at the genetic level. Two ISSR-primers (CAC)3 GC and (ACTG)5 were used, two additional DNA bands (0.15kb and 0.2kb) were observed respectively in tissue cultured Artemisia amygdalina. Direct regenera...

Small mammal communities living in sagebrush (Artemisia spp.) may be sensitive to habitat isolation and invasion by exotic grass species. Yet there have been no spatially explicit models to improve our understanding of landscape-scale factors determining small mammal occurrence or abundance. We live-trapped small mammals at 186 locations in the Wyoming Basin Ecoregional Assessment area to devel...

[This corrects the article on p. 626 in vol. 5, PMID: 25505453.].