نتایج جستجو برای: aromatase inhibitory

تعداد نتایج: 132961  

Ahmadi R Ahmadlou S Amuei S Darbouy M, Dianatpour M Zolghadri J

Background: The key enzyme of estrogen biosynthesis, aromatase cytochrome P450,is encoded by the CYP19 gene.CYP19 plays an important role in the development,function,an regulation of the female reproduction cycle. Thus, it is the potential candidate gene affecting fertility performance in human. CYP19 transcripts are expressed mainly in the ovary,testes,breast,adipose tissue and brain. Tissue e...

Journal: :Cancer research 2003
Elizabeth T Eng JingJing Ye Dudley Williams Sheryl Phung Roger E Moore Mary K Young Ugis Gruntmanis Glenn Braunstein Shiuan Chen

In breast cancer, in situ estrogen production has been demonstrated to play a major role in promoting tumor growth. Aromatase is the enzyme responsible for the conversion of androgen substrates into estrogens. This enzyme is highly expressed in breast cancer tissue compared with normal breast tissue. A wine extract fraction was recently isolated from red wine that exhibited a potent inhibitory ...

Journal: :Frontiers in neuroscience 2015
Shirin Akther Zhiqi Huang Mingkun Liang Jing Zhong Azam A. K. M. Fakhrul Teruko Yuhi Olga Lopatina Alla B. Salmina Shigeru Yokoyama Chiharu Higashida Takahiro Tsuji Mie Matsuo Haruhiro Higashida

Parental behaviors involve complex social recognition and memory processes and interactive behavior with children that can greatly facilitate healthy human family life. Fathers play a substantial role in child care in a small but significant number of mammals, including humans. However, the brain mechanism that controls male parental behavior is much less understood than that controlling female...

2013
L W Lawrence Woo Paul M Wood Christian Bubert Mark P Thomas Atul Purohit Barry V L Potter

4-{[(4-Cyanophenyl)(4H-1,2,4-triazol-4-yl)amino]methyl}phenyl sulfamate and its ortho-halogenated (F, Cl, Br) derivatives are first-generation dual aromatase and sulfatase inhibitors (DASIs). Structure-activity relationship studies were performed on these compounds, and various modifications were made to their structures involving relocation of the halogen atom, introduction of more halogen ato...

Journal: :Cancer research 1982
J H MacIndoe G R Woods L A Etre D F Covey

The presence of aromatase activity, estrogen receptors, and estrogenic responsiveness in MCF-7 human breast cancer cells has allowed this cell line to be used as a unique in vitro system for investigating the biological activities of potentially therapeutic aromatase inhibitors. We now report the results of studies which have examined the cytotoxicity, antiaromatase, and intrinsic estrogenic ac...

2018
Sehan Lee Mace G. Barron

Aromatase is a member of the cytochrome P450 superfamily responsible for a key step in the biosynthesis of estrogens. As estrogens are involved in the control of important reproduction-related processes, including sexual differentiation and maturation, aromatase is a potential target for endocrine disrupting chemicals as well as breast cancer therapy. In this work, 3D-QSAR combined with quantit...

2017
Suthat Chottanapund M.B.M. Van Duursen Anne Zwartsen Supatchaya Timtavorn Panida Navasumrit Prasat Kittakoop Sanya Sureram Mathuros Ruchirawat Martin Van den Berg

Naturally occurring depsidones from the marine fungus Aspergillus unguis are known to have substantial anti-cancer activity, but their mechanism of action remains elusive. The purpose of this study was to examine the anti-aromatase activity of two common depsidones, unguinol and aspergillusidone A, in a co-culture system of human primary breast adipose fibroblasts and hormonal responsive T47D b...

Journal: :Journal of Molecular Structure 2022

Herein we report the design and synthesis of 6-amino-quinoxaline-alkynyl derivatives, which were evaluated for their anti-cancer properties against MCF-7 breast cancer cells. A total 11 amino-quinoxaline compounds identified by molecular docking from a library over 100 compounds, to be potential aromatase (CYP19A1) inhibitors. MD simulations shed more light on equilibration stabilities enzyme-l...

Journal: :The Journal of steroid biochemistry and molecular biology 2003
Jorge R Pasqualini Patrick Caubel Andrew J Friedman Jean-Claude Philippe Gérard Samuel Chetrite

Human breast cancer tissue contains enzymes (estrone sulfatase, 17beta-hydroxysteroid dehydrogenase, aromatase) involved in the last steps of estradiol (E(2)) formation. In this tissue, E(2) can be synthesized by two main pathways: (1) sulfatase-transforms estrogen sulfates into bioactive E(2), and the (2) aromatase-converts androgens into estrogens. Quantitative assessment of E(2) formation in...

نمودار تعداد نتایج جستجو در هر سال

با کلیک روی نمودار نتایج را به سال انتشار فیلتر کنید