Herein we report the successful synthesis and isolation of tiara[6]arene, a constitutional isomer calix[6]arene consisting six phenol units linked by para-substituted methylene bridges, from an isomeric mixture asymmetrically substituted pillar[6]arene intermediates. Similar to its pentameric analogue, tiara[6]arene displays high conformational freedom in solution rich polymorphism solid state....

Microwave heating greatly accelerates Pd-catalyzed decarboxylative coupling of aromatic acids and aryl iodides, and allows the coupling of benzoic acids with unactivated arenes.

A variety of heteroarenes and electron rich arenes can be trifluoromethylated at room temperature with TMSCF3, catalytic silver and PhI(OAc)2.

Although they decompose rapidly to produce cyanocarbenes, ethynyl azides were generated from (chloroethynyl)arenes and trapped for the first time by 1,3-dipolar cycloaddition at cyclooctyne.

A gold-catalyzed mild and general oxidative homo-coupling of arenes using PhI(OAc)2 as the oxidant is described (13 examples, 31-81% yield).

The trifluoromethyl (CF3) group is becoming of increasing importance in pharmaceuticals, agrochemicals, polymers, and liquid crystals because the physical and chemical properties of molecules, such as metabolic stability, membrane permeability, and bioactivity, can be remarkably modified by installation of CF3 group(s). Therefore, the development of efficient trifluoromethylation methods has at...

Calixarenes and related compounds are established scaffolds useful as ligands and very popular as building blocks for molecular design. At the same time, the use of these compounds is virtually always defined by the ability of researchers to prepare them efficiently in useful quantities, and in a controlled fashion. As an example, calix[4]arenes, calix[6]arenes, and calix[8]arenes gained popula...

Electrophilic AlIII species have long dominated the aluminum reactivity towards arenes. Recently, nucleophilic low-valent AlI aluminyl anions showcased oxidative additions arenes C−C and/or C−H bonds. Herein, we communicate compelling evidence of an AlII radical addition reaction to benzene ring. The electron reduction a ligand stabilized precursor with KC8 in furnishes double ring instead bond...