نتایج جستجو برای: arachidonoyl dopamine

تعداد نتایج: 45801  

Journal: :iranian journal of allergy, asthma and immunology 0
"mohammad reza ostadali ghasem ahangari mohammad bagher eslami alireza razavi mohammad reza zarrindast hamid reza ahmadkhaniha

there is interrelationship between the immune and nervous systems that is accomplished by the molecular mediators. dopamine is one of the most important neurotransmitters. five different dopamine receptor genes (drd1, drd2, drd3, drd4, and drd5) have been recognized and cloned. the expression of the dopamine receptors is well characterized in the brain but little work has been done to examine t...

Journal: :Biochemical and Biophysical Research Communications 2017

Journal: :The European journal of neuroscience 2007
K A Sharkey L Cristino L D Oland M D Van Sickle K Starowicz Q J Pittman V Guglielmotti J S Davison V Di Marzo

Cannabinoid (CB) agonists suppress nausea and vomiting (emesis). Similarly, transient receptor potential vanilloid-1 (TRPV1) receptor agonists are anti-emetic. Arvanil, N-(3-methoxy-4-hydroxy-benzyl)-arachidonamide, is a synthetic 'hybrid' agonist of CB1 and TRPV1 receptors. Anandamide and N-arachidonoyl-dopamine (NADA) are endogenous agonists at both these receptors. We investigated if arvanil...

Journal: :Biochimica et biophysica acta 1975
F A Shamgar F D Collins

1. The specific radioactivities of individual molecular species of phosphoglycerides in the skeletal muscles of control rats and of rats deficient in essential fatty acids have been determined 3 h after intraperitoneal injection of ortho[32P] phosphate. 2. It has been demonstrated that the high average specific radioactivity of phosphoglycerides in muscles of rats deficient in essential fatty a...

Journal: :FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2001
D Baker G Pryce J L Croxford P Brown R G Pertwee A Makriyannis A Khanolkar L Layward F Fezza T Bisogno V Di Marzo

Spasticity is a complicating sign in multiple sclerosis that also develops in a model of chronic relapsing experimental autoimmune encephalomyelitis (CREAE) in mice. In areas associated with nerve damage, increased levels of the endocannabinoids, anandamide (arachidonoylethanolamide, AEA) and 2-arachidonoyl glycerol (2-AG), and of the AEA congener, palmitoylethanolamide (PEA), were detected her...

2015
Xin Rong Bo Wang Merlow M Dunham Per Niklas Hedde Jinny S Wong Enrico Gratton Stephen G Young David A Ford Peter Tontonoz

The role of specific phospholipids (PLs) in lipid transport has been difficult to assess due to an inability to selectively manipulate membrane composition in vivo. Here we show that the phospholipid remodeling enzyme lysophosphatidylcholine acyltransferase 3 (Lpcat3) is a critical determinant of triglyceride (TG) secretion due to its unique ability to catalyze the incorporation of arachidonate...

Journal: :Proceedings of the National Academy of Sciences of the United States of America 2001
L Hanus S Abu-Lafi E Fride A Breuer Z Vogel D E Shalev I Kustanovich R Mechoulam

Two types of endogenous cannabinoid-receptor agonists have been identified thus far. They are the ethanolamides of polyunsaturated fatty acids--arachidonoyl ethanolamide (anandamide) is the best known compound in the amide series--and 2-arachidonoyl glycerol, the only known endocannabinoid in the ester series. We report now an example of a third, ether-type endocannabinoid, 2-arachidonyl glycer...

Journal: :The Journal of neuroscience : the official journal of the Society for Neuroscience 2008
Yuliya V Medvedeva Man-Su Kim Yuriy M Usachev

Transient receptor potential vanilloid receptor 1 (TRPV1)-mediated release of neuroactive peptides and neurotransmitters from the peripheral and central terminals of primary sensory neurons can critically contribute to nociceptive processing at the periphery and in the CNS. However, the mechanisms that link TRPV1 activation with Ca2+ signaling at the release sites and neurosecretion are poorly ...

Journal: :Bulletin de l'Academie nationale de medecine 2014
Jean Costentin

Tetrahydrocannabinol, the main psychotropic component of Cannabis indica, is an addictive drug with multiple effects including both peripheral and central damages. All these effects are due to interference with endocannabinoidergic transmission. This endocannabinoid system subtly regulates many physiologicalfunctions. This regulation involves various ligands derived from arachidonic acid (anand...

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