PURPOSE Nasal cytology is important in the diagnosis and treatment of nasal inflammatory diseases. Treatment of allergic rhinitis (AR) according to nasal cytology has not been fully studied. We plan to explore the individualized treatment of AR according to nasal cytology. METHODS Nasal cytology from 468 AR patients was examined for inflammatory cell quantity (grade 0-5) and the percentage of...

BACKGROUND The chemopreventive effects of resveratrol (RSV) on prostate cancer have been well established; the androgen receptor (AR) plays pivotal roles in prostatic tumorigenesis. However, the exact underlying molecular mechanisms about the effects of RSV on AR have not been fully elucidated. A model system is needed to determine whether and how RSV represses AR transcriptional activity. ME...

Prostate cancer is an androgen receptor (AR)-driven disease and post-translational modification of AR is critical for AR activation. We previously reported that Arrest-defective protein 1 (ARD1) is an oncoprotein in prostate cancer. It acetylates and activates AR to promote prostate tumorigenesis. However, the ARD1-targeted residue within AR and the mechanisms of the acetylation event in prosta...

allergic rhinitis (ar) is an ige-mediated upper airway disease, and its impact on asthma has been widely recognized. protein tyrosine phosphatase non-receptor 22 (ptpn22) gene and the cytotoxic t-lymphocyte–associated antigen 4 (ctla-4) gene polymorphisms have been reported to be associated with several immune-related diseases. here we investigated the reffect of these two genes’ polymorphisms ...

background: interleukin-17 (il-17), as a potent proinflammatory cytokine, has a critical role in post liver transplant outcomes. however, there is not much information about the effects of il-17 cytokine on acute liver rejection. objective: to evaluate the role of il-17 in post-liver transplant acute rejection. methods: ninety seven adult liver transplant patients who enrolled in this cross sec...

The androgen receptor (AR) gene polymorphism in humans is linked to aggression and may also be linked to reproduction. Here we report associations between AR gene polymorphism and aggression and reproduction in two small-scale societies in northern Tanzania (Africa)--the Hadza (monogamous foragers) and the Datoga (polygynous pastoralists). We secured self-reports of aggression and assessed gene...

Persistent androgen receptor (AR) transcriptional activity underlies resistance to AR-targeted therapy and progression to lethal castration-resistant prostate cancer (CRPC). Recent success in retargeting persistent AR activity with next generation androgen/AR axis inhibitors such as enzalutamide (MDV3100) has validated AR as a master regulator during all stages of disease progression. However, ...