Costello-Boerrigter, Lisa C., William B. Smith, Guido Boerrigter, John Ouyang, Christopher A. Zimmer, Cesare Orlandi, and John C. Burnett, Jr. Vasopressin-2-receptor antagonism augments water excretion without changes in renal hemodynamics or sodium and potassium excretion in human heart failure. Am J Physiol Renal Physiol 290: F273–F278, 2006. First published September 27, 2005; doi:10.1152/aj...

G-protein-coupled receptors (GPCRs) such as the vasopressin-2 receptor (V(2)R) are an important class of drug targets. We developed an efficient screen for GPCR-induced cAMP elevation using as read-out cAMP activation of cystic fibrosis transmembrane conductance regulator (CFTR) Cl(-) channels. Fischer rat thyroid cells expressing CFTR and a halide-sensing yellow fluorescent protein (H148Q/I152...

diabetes mellitus is a metabolic disorder characterized by chronic hyperglycemia. the management of the blood glucose level is a critical strategy in the control of diabetes complications. inhibitors of carbohydrate hydrolyzing enzymes have been useful as oral hypoglycemic drugs for the control of hyperglycemia especially in patients with type ii disables mellitus. the goal of the present study...

objective(s): mindium laevigatum is an endemic plant of iran and turkey and is widely used as blood purifier, antiasthma and antidyspnea in traditional medicine. chemical composition of volatile materials of the plant and its antioxidant, antimicrobial and cytotoxic activities were reported in this study. materials and methods: simultaneous distillation-extraction (sde) and gc-mass-fid analysis...

seaweeds have caused an emerging interest in the biomedical area, mainly due to their contents of bioactive substances which show great potential as anti-inflammatory, anti-microbial, anti-viral and anti-tumoral drugs. despite the diversity in quality and quantity of the mediterranean tunisian coast flora, with its large contains of marine organisms and seaweeds, most of them have not yet been ...

the methanolic extracts, infusions, decoctions and hydrosols of six plants were investigated for their total phenolic contents, antioxidant and antimicrobial activities: mentha piperita (peppermint), thymus vulgaris   (thyme), melissa officinalis (lemon balm), ocimum basilicum (basil), rosmarinus officinalis (rosemary) and     salvia officinalis     (sage) (lamiaceae). total phenolic contents w...

a new series of transition metal complexes of co(ii), ni(ii), cu(ii) and zn(ii), has beensynthesized from the knoevenagel condensate schiff base ligand(l) derived from β-ketoanilideand furfural with o-phenylenediamine and diethylmalonate. structural features were determinedby spectral and analytical techniques. square-planar geometry has been adopted by thecomplexes except cobalt complex which ...

diabetes mellitus is a metabolic disorder affecting carbohydrate, fat and protein metabolism that affects nearly 10% of the population every year. the treatment of diabetes mellitus has been confined to use of oral hypoglycemic agents and insulin, the former being reported to possess serious side effects. this leads to increasing demand for herbal products with antidiabetic factor with little s...

the aim of the study is to examine in-vitro antioxidant and antimicrobial activity of the acetonic and methanolic extracts of the mushrooms boletus aestivalis, boletus edulis and leccinum carpini. antioxidant activity was evaluated by using free radical scavenging activity and reducing power. in addition, total content of phenol and flavonoid in extracts were determined as pyrocatechol equivale...