نتایج جستجو برای: apoptotic protease activating factor 1 apaf 1

تعداد نتایج: 3426648  

Journal: :Clinical cancer research : an official journal of the American Association for Cancer Research 2004
Benjamin Besse Céline Candé Jean-Philippe Spano Antoine Martin David Khayat Thierry Le Chevalier Thomas Tursz Laure Sabatier Jean-Charles Soria Guido Kroemer

The proapoptotic protein apoptosis protein activating factor-1 (Apaf-1), which is normally located in the cytoplasm, can translocate to the nucleus before non-small cell lung carcinoma (NSCLC) cells manifest signs of apoptosis such as mitochondrial damage, caspase activation, or chromatin condensation. This may indicate a stage of imminent apoptosis. Importantly, we found that 24% (15 of 62) of...

Journal: :Revista espanola de enfermedades digestivas : organo oficial de la Sociedad Espanola de Patologia Digestiva 2005
D Olivares J P Gisbert J M Pajares

NF-κB: nuclear factor κB; TNF-α: tumor necrosis factor α; DD: death domain; FADD: Fas-associated death domain; FasL: Fas receptor ligand; TNFR: TNF receptor; TRADD: TNFR-associated death domain; TRAF: TNFR-associated factor; COX: cyclooxygenase; PG: prostaglandin; iNOS: inducible nitric oxide synthase; NO: nitric oxide; MDR-1: multiple drug resistance gene; IL: interleukin; EGF: epithelial grow...

Journal: :Journal of neural transmission. Supplementum 2006
J B Schulz

Apoptosis, whether caspase-dependent or caspase-independent, has been implicated as one of the important mechanisms leading to the death of dopaminergic neurons in the substantia nigra of Parkinson's disease patients. Major advances of our understanding of apoptosis have been achieved in studies of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) toxicity in mice and monkeys and 6-hydroxydop...

2016
Ying Wang Yang Cao Qing Zhu Xianfeng Gu Yi Zhun Zhu

Apaf-1 is a central component in the apoptosis regulatory network for the treatment of apoptosis related diseases. Excessive Apaf-1 activity induced by myocardial ischemia causes cell injury. No drug targeted to Apaf-1 for treating myocardial ischemia has been reported to the best of our knowledge. In the present work, we synthesized a novel compound, ZYZ-488, which exhibited significant cardio...

2017
Lingling Si Xinhui Yang Xinyan Yan Yanming Wang Qiusheng Zheng

The aim of the present study was to investigate whether an increase in cyclin-dependent kinase 2 (CDK2) activity is involved in apoptosis of human bladder cancer T24 cells induced by isoliquiritigenin (ISL). The viability of T24 cells was estimated using a sulforhodamine B assay. Cell morphological changes were examined using Hoechst 33258 staining. The apoptotic rate was determined by staining...

2012
Wen-Wen Huang Jai-Sing Yang Meng-Wei Lin Po-Yuan Chen Shang-Ming Chiou Fu-Shin Chueh Yu-Hsuan Lan Shu-Jen Pai Minoru Tsuzuki Wai-Jane Ho Jing-Gung Chung

Cucurbitacin E, a tetracyclic triterpenes compound extracted from cucurbitaceous plants, has been shown to exhibit anticancer and anti-inflammatory activities. The purpose of this study was to elucidate whether cucurbitacin E promotes cell cycle arrest and induces apoptosis in T24 cells and further to explore the underlying molecular mechanisms. The effects of cucurbitacin E on T24 cell's growt...

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