نتایج جستجو برای: apolipoprotein apo a

تعداد نتایج: 13438679  

Journal: :The Journal of clinical investigation 1989
E A Brinton S Eisenberg J L Breslow

High levels of HDL-cholesterol (HDL-C) protect against coronary heart disease susceptibility, but the metabolic mechanisms underlying elevated HDL-C levels are poorly understood. We now report the turnover of isologous radioiodinated HDL apolipoproteins, apo A-I and apo A-II, in 15 female subjects on a metabolic diet with HDL-C levels ranging from 51 to 122 mg/dl. The metabolic parameters, frac...

Journal: :Clinical chemistry 1988
N Alsayed T B Drüeke B Lacour

A new immunoaffinity technique for purifying anti-apolipoprotein CIII antibodies has been developed by isolating bands of apo CIII2 from isoelectric focusing (IEF) gel. Total apo C was obtained from delipidated very-low-density lipoprotein by chromatography on Sephacryl S 200. Apo CIII2 was separated from the apo CII band by IEF on polyacrylamide gel with use of pH 4-6 ampholytes. After sonicat...

Journal: :The American journal of clinical nutrition 1987
J J Badimon C R Fleming J Patton S J Mao

We have studied the plasma lipid and apolipoprotein profiles of 19 patients with intestinal failure who are receiving long-term total parenteral nutrition (TPN). These patients had significantly reduced levels of total and HDL cholesterol and normal levels of triglycerides. Radioimmunoassay determination of apolipoproteins showed a 30% and 50% reduction in apo A-I and A-II levels, respectively....

Journal: :Arteriosclerosis and thrombosis : a journal of vascular biology 1991
G Agnani J M Bard L Candelier S Delattre J C Fruchart V Clavey

In this study we measured the binding parameters of different apolipoprotein (apo) B-containing lipoproteins to the low density lipoprotein (LDL) receptor of HeLa cells. Our goal was to determine the respective roles of the different apolipoproteins of these particles, with particular emphasis on apos B, E, and C-III. Very low density lipoprotein from hypertriglyceridemic subjects (B to E molar...

Journal: :The Journal of clinical investigation 1984
R W Milne P K Weech L Blanchette J Davignon P Alaupovic Y L Marcel

Two major species of human apolipoprotein (apo) B have been identified, apo B-48 and apo B-100, which are the predominant forms in chylomicrons and very low density lipoproteins (VLDL), respectively. Due to defective hepatic clearance, apo B-48 containing lipoproteins accumulate in the plasma of subjects with type III hyperlipoproteinemia. In the present study, we have used immunoaffinity chrom...

Journal: :Journal of lipid research 2010
Tanja X Pedersen Sally P McCormick Sotirios Tsimikas Susanne Bro Lars B Nielsen

Uremic patients have increased plasma lipoprotein(a) [Lp(a)] levels and elevated risk of cardiovascular disease. Lp(a) is a subfraction of LDL, where apolipoprotein(a) [apo(a)] is disulfide bound to apolipoprotein B-100 (apoB). Lp(a) binds oxidized phospholipids (OxPL), and uremia increases lipoprotein-associated OxPL. Thus, Lp(a) may be particularly atherogenic in a uremic setting. We therefor...

Journal: :Proceedings of the National Academy of Sciences of the United States of America 1996
W Weng J L Breslow

Apolipoprotein (apo) A-II is the second most abundant apolipoprotein in high density lipoprotein (HDL). To study its role in lipoprotein metabolism and atherosclerosis susceptibility, apo A-II knockout mice were created. Homozygous knockout mice had 67% and 52% reductions in HDL cholesterol levels in the fasted and fed states, respectively, and HDL particle size was reduced. Metabolic turnover ...

Journal: :journal of nutritional sciences and dietetics 0
laleh keramat department of cellular and molecular nutrition, school of nutritional sciences and dietetics, tehran university of medical sciences, tehran, iran mohammadreza eshraghian department of biostatistics and epidemiology, school of public health, tehran university of medical sciences, tehran, iran mahmoud djalali department of cellular and molecular nutrition, school of nutritional sciences and dietetics, tehran university of medical sciences, tehran, iran gity sotoudeh department of community nutrition, school of nutritional sciences and dietetics, tehran university of medical sciences, tehran, iran haleh sadrzadeh-yeganeh department of community nutrition, school of nutritional sciences and dietetics, tehran university of medical sciences, tehran, iran fariba koohdani department of cellular and molecular nutrition, school of nutritional sciences and dietetics, and diabetes research center, endocrinology and metabolism clinical sciences institute, tehran university of medical sciences, tehran, iran

b a ckground: the objective was to investigate the relationship between serum interleukin-18 (il-18), pentraxin 3 (ptx3), and high-sensitivity c-reactive protein (hs-crp) levels with body mass index (bmi) and abdominal obesity and also the interaction between genetic variants of apolipoprotein a-ii (apo a-ii) and obesity on the levels of these factors in type 2 diabetes patients (t2d). m ethods...

Journal: :British heart journal 1986
P N Durrington L Hunt M Ishola J Kane W P Stephens

The serum high density lipoprotein (HDL) subfractions, HDL2, and HDL3, and serum apolipoprotein AI and B (apo AI and B) were evaluated as potential indicators of the risk of ischaemic heart disease in men aged less than 60 years who had previously had a myocardial infarction and in controls with a similar socioeconomic background who had no history of myocardial ischaemia. Discriminant analysis...

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