High-density lipoprotein (HDL) particles are characterized by their heterogeneity in composition, structure, and biological properties. In addition to the major structural protein apolipoprotein A1, HDL proteomes and lipidomes show great diversity. Such constituents presumably carry out the multitude of HDL functions, for example, reverse cholesterol transport, antioxidant, anti-inflammatory, a...

Background. Hypercholesterolemia and inflammation both contribute to the pathogenesis of atherosclerosis its clinical manifestations. Statins, possessing lipid-lowering anti-inflammatory properties, are currently recommended in all ischemic syndromes. Purpose. To compare effects atorvastatin rosuvastatin on lipid inflammatory markers patients with acute coronary syndromes (ACS). Methods. Two hu...

High-density lipoprotein (HDL) particles are characterized by their heterogeneity in composition, structure, and biological properties. In addition to the major structural protein apolipoprotein A1, HDL proteomes and lipidomes show great diversity. Such constituents presumably carry out the multitude of HDL functions, for example, reverse cholesterol transport, antioxidant, anti-inflammatory, a...

We have elucidated the structures of N-linked sugar chains of human apolipoprotein (apo) B-100 (Arch Biochem Biophys 1989; 273:197-205). To investigate the role of the carbohydrate moieties of apolipoprotein B-100, we determined the structures of the N-linked sugar chains of apo B-100 purified from low density lipoprotein (LDL) of a Watanabe heritable hyperlipidemic (WHHL) rabbit and compared t...

HNF-4 (hepatocyte nuclear factor 4) is a protein enriched in liver extracts that binds to sites required for the transcription of the genes for transthyretin (TTR), the carrier protein in the serum for vitamin A and thyroid hormone, and for apolipoprotein CIII (apoCIII), a major constituent of chylomicrons and very low-density lipoproteins (VLDL). Synthetic oligonucleotides derived from amino a...

Abstract Context To enable prevention and treatment of age-related macular degeneration (AMD), understanding risk factors for AMD is important. Objective We tested the hypotheses that elevated plasma apolipoprotein A1 high-density lipoprotein (HDL) cholesterol low levels low-density (LDL) are associated with increased AMD. Methods From Danish general population, we studied 106 703 16 032 indivi...