BACKGROUND We introduced a hypometabolic convergence index (HCI) to characterize in a single measurement the extent to which a person's fluorodeoxyglucose positron emission tomogram (FDG PET) corresponds to that in Alzheimer's disease (AD). Apolipoprotein E ε4 (APOE ε4) gene dose is associated with three levels of risk for late-onset AD. We explored the association between gene dose and HCI in ...

Enduring interest in the Apolipoprotein E (ApoE) polymorphism is ensured by its evolutionary-driven uniqueness in humans and its prominent role in geriatrics and gerontology. We use large samples of longitudinally followed populations from the Framingham Heart Study (FHS) original and offspring cohorts and the Long Life Family Study (LLFS) to investigate gender-specific effects of the ApoE4 all...

AIM Several clinical trials have indicated that dehydroepiandrosterone (DHEA) reduces coronary events associated with atherosclerosis. The aim of this study was to examine the inhibitory effect of DHEA on atherosclerosis and the mechanisms involved. METHODS Apolipoprotein E-knockout (apoE-KO) mice were fed an atherogenic high-cholesterol diet with or without 0.4% (w/w) DHEA for 12 weeks. RE...

Apolipoprotein (apo) E polymorphism was examined in a population of Italian blood donors. A significantly reduced frequency of the epsilon 4 allele was observed in comparison to a combined Caucasian population. Apo E polymorphism was also associated with significant differences in plasma lipid and lipoprotein levels. Notably, total and low-density lipoprotein cholesterol as well as triglyceride...

introduction: hyperlipidemia is a risk factor for atherosclerosis and cardiovascular diseases. nuts such as almonds are high in unsaturated lipids and antioxidants. some studies indicate that nuts have beneficial effects on cardiovascular system. therefore, the aim of this study was evaluation of the effectiveness of shelled almonds on reduction of blood lipid and lipoprotein levels in hyperlip...

1994年5月 か ら7月 の期 間 に, 山梨 県 に在 住 した全 て の百歳 以 上 の高齢 者35名 を対 象 とした. 山梨 医科 大 学倫 理委 員長 の承 諾 を得 た上 で対 象 者 を訪 問 した. イ ン フォー ム ドコ ンセ ン トを得 て全例 を調 査 し, 許可 の 得 られ た33名 で遺伝 子解 析 と血 液生 化学 検 査用 に採 血 を行 なった. 調査 で は demographic な要 因 等 に加 えて 痴呆 の評 価 を行 な った. DSMIIIR3)に よ り痴 呆 の有 無 を評 価 し た が, 痴 呆 に該 当 し な い場 合 はHDSR4)の cut off point よ り21点 以 上 あれ ば痴 呆 な し, 20点 以 下 は痴 呆 で はな い認知 機能 障 害 として扱 った. また痴 呆 と判 断 され た例...

Terminal-area aircraft intent inference (T-AII) is a prerequisite to detect and avoid potential aircraft conflict in the terminal airspace. T-AII challenges the state-of-the-art AII approaches due to the uncertainties of air traffic situation, in particular due to the undefined flight routes and frequent maneuvers. In this paper, a novel T-AII approach is introduced to address the limitations b...