Total serum lipids, as well as apolipoproteins A-I (apo A-I) and B (apo B), were determined in 74 patients with chronic liver failure without cholestasis and in 82 normal subjects. The VLDL, LDL and HDL lipid fractions were reduced in the liver failure group by 36%, 24% and 46%, respectively (P < 0.001). Apolipoproteins A-I and B were also reduced by 26% and 25%, respectively (P < 0.001). Howev...

We have reported previously on two truncations of apolipoprotein B (apo B-40 and apo B-89) in a kindred with hypobetalipoproteinemia. Premature stop codons were found to be responsible for both apo B-40 and apo B-89, but the physiologic mechanisms accounting for the reduced plasma concentrations of these proteins have not been determined in vivo. This study investigates the metabolism of apo B-...

HDL metabolism and atherosclerosis were studied in apo E knockout (KO) mice overexpressing human apo AI, a des- (190-243)-apo AI carboxyl-terminal deletion mutant of human apo AI or an apo AI-(1-189)-apo AII-(12-77) chimera in which the carboxyl-terminal domain of apo AI was substituted with the pair of helices of apo AII. HDL cholesterol levels ranked: apo AI/apo E KO approximately apo AI-(1-1...

Apo A-IMilano is a mutant form of apo A-I in which cysteine is substituted for arginine at amino acid 173. Subjects with apo A-IMilano are characterized by having low levels of plasma HDL cholesterol and apo A-I. To determine the kinetic etiology of the decreased plasma levels of the apo A-I in these individuals, normal and mutant apo A-I were isolated, radiolabeled with either 125I or 131I, an...

Bu çalışma, %4 kadife çiçeği (Tagetes erecta), 0 ve 100 mg/kg sentetik apo-ester içeren diyetlerle 60 gün beslenen sarı prenses balığının (Labidochromis caeruleus) deri rengi yetiştiricilik parametreleri üzerindeki etkilerini belirlemek amacıyla gerçekleştirilmiştir. Deri rengi, kolorimetrik yöntemle bir yansıtma spektroskopisi kullanılarak ölçülmüştür. Kadife apo-esterin balıkların renk (L*,a*...

Background: Functional hypothalamic menstrual disorder (FHMD) has a destructive effect on the athlete&rsquo;s bone mineral density and cardiovascular system. Utilizing hormone replacement therapy to treat FHMD in athletes is controversial. This study was conducted to examine the effect of hormone therapy on bone density and the cardiovascular system of professional female athletes with FHMD. ...

For the impulsive ankle push-off (APO) observed in human walking two muscle-tendon-units (MTUs) spanning joint play an important role: Gastrocnemius (GAS) and Soleus (SOL). GAS SOL load Achilles tendon to store elastic energy during stance followed by a rapid release APO. We use neuromuscular simulation (NMS) bipedal robot investigate role of on optimize for robust gait then sequentially replac...

The influence of different fibrates on apolipoprotein metabolism was investigated. Administration of fenofibrate provoked a dose-dependent decrease in plasma cholesterol concentration that was already evident after 1 day. Intestinal apolipoprotein (apo) A-I and apo A-IV mRNA levels remained fairly constant. In contrast, liver apo A-I, apo A-II, and apo A-IV mRNA levels decreased in a dose-depen...